ArticleJournal of clinical hypertension (Greenwich, Conn.)2008
Resistant arterial hypertension is associated with higher blood levels of complement C3 and C-reactive protein.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Association between circulatory complement activation and hypertensive renal damage: a case-control study.Renal failure · 2024Article
- Association between Cardiovascular Health, C-Reactive Protein, and Comorbidities in Spanish Urban-Dwelling Overweight/Obese Hypertensive Patients.Journal of cardiovascular development and disease · 2023Article
- Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach.Journal of translational medicine · 2023Article
- The potential role of complement alternative pathway activation in hypertensive renal damage.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Potential Involvement of Complement Activation in Kidney Vascular Lesions of Arterionephrosclerosis.Frontiers in medicine · 2022Article
- The Complement System in Metabolic-Associated Kidney Diseases.Frontiers in immunology · 2022Review
- Autoimmune-mediated renal disease and hypertension.Clinical science (London, England : 1979) · 2021Review
- Myeloid cells, tissue homeostasis, and anatomical barriers as innate immune effectors in arterial hypertension.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Hypertension Is Associated with Increased Risk of Diabetic Lung.International journal of environmental research and public health · 2020Article
- Inflammation in Hypertension.The Canadian journal of cardiology · 2020Review
- Correlation between neutrophil-to-lymphocyte ratio and kidney dysfunction in undiagnosed hypertensive population from general health checkup.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Serum C3 complement levels in ANCA associated vasculitis at diagnosis is a predictor of patient and renal outcome.Journal of nephrology · 2018Article
- Immune system deregulation in hypertensive patients chronically RAS suppressed developing albuminuria.Scientific reports · 2017Article
- The relationship between neutrophil to lymphocyte ratio and artery stiffness in subtypes of hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis.International journal of hypertension · 2016Article
- Increased Neutrophil to Lymphocyte Ratio in Patients With Resistant Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population.PloS one · 2012Article
- Serum C-reactive protein (CRP) levels in cancer patients are linked with tumor burden and are reduced by anti-hypertensive medication.Inflammation · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arterial hypertension is associated with increased plasma levels of complement C3, C4, and C-reactive protein (CRP). The aim of the study was to compare these laboratory markers in patients with resistant arterial hypertension (RAH) and controlled arterial hypertension (CAH). Patients with RAH (n = 34), those with CAH (n = 34), and 26 normotensive controls were included. White blood cell count, erythrocyte sedimentation rates, and blood levels of complement components C3, C4, and high-sensitivity C-reactive protein (hs-CRP) were compared among the study groups. In the RAH group, serum C3 (183.9+/-47.5 mg/dL) and hs-CRP (6.9+/-5.8 mg/L) were higher than in the CAH group (C3, 123.1+/-42.3 mg/dL; P < .001, hs-CRP, 4.2+/-4.8; P = .021, respectively). Significant positive correlations between systolic blood pressure and C3 (r = 0.6481; P < .001) and hs-CRP (r = 0.3968; P = .02) were observed in the RAH group. RAH is associated with higher blood levels of C3 and CRP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.