Evidence map›Paper›PMID 18844215›Full record

ReviewInflammatory bowel diseases2009

Applications of proteomics in the study of inflammatory bowel diseases: Current status and future directions with available technologies.

Philip Alex, Marjan Gucek, Xuhang Li

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Inflammatory bowel diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 56 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Serum protein profiling of adults and children with Crohn disease.Journal of pediatric gastroenterology and nutrition · 2015
    Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Biomarkers in inflammatory bowel disease: current practices and recent advances.Translational research : the journal of laboratory and clinical medicine · 2012
    Review
  18. Review
  19. Janice Drew's work on diet and cancer.World journal of gastrointestinal pathophysiology · 2011
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Philip AlexDivision of Gastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.
Marjan Gucek
Xuhang Li
Johns Hopkins University · US

Funding

Hopkins Digestive Diseases Research Development CenterR24DK064388 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2003 to 2010
$4.6M
Development of Biomarkers for IBD Using Protein ChipsR21DK077064 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI LI, XUHANG · 2007 to 2010
$515k
NHE3 Regulation by Lipid Rafts and Hsc70K01DK062264 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI LI, XUHANG · 2002 to 2004
$364k
NIDDK NIH HHS K01 DK062264NIDDK NIH HHS KO1-DK62264NIDDK NIH HHS R21 DK077064NIDDK NIH HHS R24 DK064388NIDDK NIH HHS R24-DK64388
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBD) are chronic, heterogeneous, and multifactorial intestinal inflammatory disorders. Major challenges in IBD research include identification of major pathogenic alterations of genes/proteins as well as effective biomarkers for early diagnosis, prognosis, and prediction of therapeutic response. Since proteins govern cellular structure and biological function, a wide selection of proteomic approaches enables effective characterization of IBD pathogenesis by investigating the dynamic nature of protein expression, cellular and subcellular distribution, posttranslational modifications, and interactions at both the cellular and subcellular levels. The aims of this review are to 1) highlight the current status of proteomic studies of IBD, and 2) introduce the available and emerging proteomic technologies that have potential applications in the study of IBD. These technologies include various mass spectrometry technologies, quantitative proteomics (2D-PAGE, ICAT, SILAC, iTRAQ), protein/antibody arrays, and multi-epitope-ligand cartography. This review also presents information and methodologies, from sample selection and enrichment to protein identification, that are not only essential but also particularly relevant to IBD research. The potential future application of these technologies is expected to have a significant impact on the discovery of novel biomarkers and key pathogenic factors for IBD.

Indexed as

BiomarkersHumansInflammatory Bowel DiseasesProteomicsBiomarkers

Identifiers

PMID18844215
PMCPMC2667948
OpenAlexW2048010739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.