Evidence map›Paper›PMID 18843742›Full record

SynthesisThe Cochrane database of systematic reviews2008

Interventions for heartburn in pregnancy.

Therese Dowswell, James P Neilson

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Interventions for heartburn in pregnancy.The Cochrane database of systematic reviews · 2015
    Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Heartburn in pregnancy.BMJ clinical evidence · 2015
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Therese DowswellCochrane Pregnancy and Childbirth Group, School of Reproductive and Developmental Medicine, Division of Perinatal and Reproductive Medicine, University of Liverpool , First Floor, Liverpool Women's NHS Foundation Trust, Liverpool, UK, L8 7SS.
James P Neilson
University of Liverpool · GB

Funding

Department of Health SRP/10/4001/02
6 · The paper itself

Abstract

backgroundHeartburn is a common symptom in pregnancy affecting up to 80% of women in the third trimester. The reasons for the increase in symptoms in pregnancy are not well understood, but the effects of pregnancy hormones on the lower oesophageal sphincter and gastric clearance are thought to play a part. A range of interventions have been used to relieve symptoms including advice on diet and lifestyle, antacids, antihistamines, and proton pump inhibitors. The safety and effectiveness of these interventions to relieve heartburn in pregnancy have not been established.

objectivesTo assess the effect of interventions to relieve heartburn in pregnancy. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (April 2008). SELECTION CRITERIA: We included randomised controlled trials evaluating interventions to relieve heartburn. DATA COLLECTION AND ANALYSIS: We assessed eligibility for inclusion and extracted data independently. MAIN

resultsThree studies were eligible for inclusion, together they included a total of 286 women. All three were placebo controlled trials, each examining a different medication to relieve heartburn (intramuscular prostigmine, an antacid preparation and an antacid plus ranitidine). All three produced positive findings in favour of the intervention groups. It was not possible to pool findings from studies to produce an overall treatment effect. AUTHORS'

conclusionsThere was little information to draw conclusions on the overall effectiveness of interventions to relieve heartburn in pregnancy.

Indexed as

FemaleHeartburnHumansPregnancyPregnancy ComplicationsRandomized Controlled Trials as Topic

Identifiers

PMID18843742
PMCPMC4071443
OpenAlexW2108038112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.