Evidence map›Paper›PMID 18843530›Full record

SynthesisAIDS and behavior2010

Couples-focused behavioral interventions for prevention of HIV: systematic review of the state of evidence.

Jennifer Burton, Lynae A Darbes, Don Operario

Registry-linked trialOpen access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in AIDS and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06639932 (Evaluating the Effects of the We-INtervention Among Chinese HIV-serodiscordant Male Couples in a Randomized Controlled Trial), which is not on this map. Cited by 154 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 9 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06639932 narecruitingnot on this mapstarted 2025, after this paper: background citation

Evaluating the Effects of the We-INtervention Among Chinese HIV-serodiscordant Male Couples in a Randomized Controlled Trial

TypeinterventionalSponsorCity University of Hong KongRan2025 to 2027Enrolled320ConditionsHIVArmsWe-INtervention, Usual Care Group
3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 9 syntheses or guidelines pooled it, 304 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Results of a Couples-Based Randomized Controlled Trial Aimed to Increase Testing for HIV.Journal of acquired immune deficiency syndromes (1999) · 2019
    Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Jennifer BurtonDepartment of Social Policy and Social Work, University of Oxford, Oxford, Oxfordshire, England.
Lynae A Darbes
Don Operario
Brown University · USOxford Policy Management · GBSan Francisco AIDS Foundation · US

Funding

Gender, Relationship Dynamics, and HIV RiskR01DA018621 · NIDA · UNIVERSITY OF OXFORD · PI OPERARIO, DON · 2006 to 2009
$1.3M
Couples-Based HIV Prevention in South AfricaK08MH072380 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DARBES, LYNAE A · 2004 to 2008
$832k
NIDA NIH HHS R01 DA018621NIDA NIH HHS R01DA018621NIMH NIH HHS K08 MH072380NIMH NIH HHS K08MH072380
6 · The paper itself

Abstract

HIV is frequently transmitted in the context of partners in a committed relationship, thus couples-focused HIV prevention interventions are a potentially promising modality for reducing infection. We conducted a systematic review of studies testing whether couples-focused behavioral prevention interventions reduce HIV transmission and risk behavior. We included studies using randomized controlled trial designs, quasi-randomized controlled trials, and nonrandomized controlled studies. We searched five electronic databases and screened 7,628 records. Six studies enrolling 1,084 index couples met inclusion criteria and were included in this review. Results across studies consistently indicated that couples-focused programs reduced unprotected sexual intercourse and increased condom use compared with control groups. However, studies were heterogeneous in population, type of intervention, comparison groups, and outcomes measures, and so meta-analysis to calculate pooled effects was inappropriate. Although couples-focused approaches to HIV prevention appear initially promising, additional research is necessary to build a stronger theoretical and methodological basis for couples-focused HIV prevention, and future interventions must pay closer attention to same-sex couples, adolescents, and young people in relationships.

Indexed as

Family CharacteristicsSexual BehaviorCognitive Behavioral TherapyHealth BehaviorHealth PromotionHIV InfectionsHumansInterpersonal RelationsRandomized Controlled Trials as TopicSexually Transmitted Diseases

Identifiers

PMID18843530
PMCPMC3640442
OpenAlexW2040315999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.