ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Mammalian hibernation as a model of disuse osteoporosis: the effects of physical inactivity on bone metabolism, structure, and strength.
Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Using Organoids to Unlock the Potential of Human Torpor for Spaceflight.Current stem cell reports · 2026Article
- Connexin hemichannels drive lactation-induced osteocyte acidification and perilacunar-canalicular remodeling.Cell reports · 2024Article
- Female Health Across the Tree of Life: Insights at the Intersection of Women's Health, One Health and Planetary Health.PNAS nexus · 2022Article
- Differential bone remodeling mechanism in hindlimb unloaded rats and hibernating Daurian ground squirrels: a comparison between artificial and natural disuse.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Transcriptional changes and preservation of bone mass in hibernating black bears.Scientific reports · 2021Article
- Assessment of Osteocytes: Techniques for Studying Morphological and Molecular Changes Associated with Perilacunar/Canalicular Remodeling of the Bone Matrix.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Denning in brown bears.Ecology and evolution · 2020Review
- Calcium homeostasis during hibernation and in mechanical environments disrupting calcium homeostasis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Review
- Hibernating bear serum hinders osteoclastogenesis in-vitro.PloS one · 2020Article
- Investigating Osteocytic Perilacunar/Canalicular Remodeling.Current osteoporosis reports · 2019Review
- Hibernating astronauts-science or fiction?Pflugers Archiv : European journal of physiology · 2019Review
- Krogh's principle for musculoskeletal physiology and pathology.Journal of musculoskeletal & neuronal interactions · 2018Article
- Article
- A dramatic blood plasticity in hibernating and 14-day hindlimb unloading Daurian ground squirrels (Spermophilus dauricus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- The effects of hibernation and forced disuse (neurectomy) on bone properties in arctic ground squirrels.Physiological reports · 2016Article
- Proteomics approaches shed new light on hibernation physiology.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
- Serum immune-related proteins are differentially expressed during hibernation in the American black bear.PloS one · 2013Article
- Preservation of bone mass and structure in hibernating black bears (Ursus americanus) through elevated expression of anabolic genes.Functional & integrative genomics · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Reduced skeletal loading typically leads to bone loss because bone formation and bone resorption become unbalanced. Hibernation is a natural model of musculoskeletal disuse because hibernating animals greatly reduce weight-bearing activity, and therefore, they would be expected to lose bone. Some evidence suggests that small mammals like ground squirrels, bats, and hamsters do lose bone during hibernation, but the mechanism of bone loss is unclear. In contrast, hibernating bears maintain balanced bone remodeling and preserve bone structure and strength. Differences in the skeletal responses of bears and smaller mammals to hibernation may be due to differences in their hibernation patterns; smaller mammals may excrete calcium liberated from bone during periodic arousals throughout hibernation, leading to progressive bone loss over time, whereas bears may have evolved more sophisticated physiological processes to recycle calcium, prevent hypercalcemia, and maintain bone integrity. Investigating the roles of neural and hormonal control of bear bone metabolism could give valuable insight into translating the mechanisms that prevent disuse-induced bone loss in bears into novel therapies for treating osteoporosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.