ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2008
Genetic variation in calcium-sensing receptor and risk for colon cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- CASR rs1801725 polymorphism is associated with the risk and prognosis of colorectal cancer: A case-control study.Journal of clinical laboratory analysis · 2020Pooled it
- Review
- Quantitative assessment of the clinical susceptibility of calcium-sensing receptor polymorphisms in cancer patients.Cancer management and research · 2018Article
- Vitamin D receptor and calcium-sensing receptor polymorphisms and colorectal cancer survival in the Newfoundland population.British journal of cancer · 2017Article
- Alanine to Serine Variant at Position 986 of Calcium Sensing Receptor and Colorectal Cancer Risk.Iranian journal of cancer prevention · 2016Article
- Cross Talk between the Calcium-Sensing Receptor and the Vitamin D System in Prevention of Cancer.Frontiers in physiology · 2016Review
- Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review.OncoTargets and therapy · 2016Review
- The calcium-sensing receptor: A promising target for prevention of colorectal cancer.Biochimica et biophysica acta · 2015Article
- Association of Dietary Vitamin D and Calcium With Genetic Polymorphisms in Colorectal Neoplasia.Journal of cancer prevention · 2015Review
- Gene-diet interactions and their impact on colorectal cancer risk.Current nutrition reports · 2015Article
- No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Polymorphisms in the calcium-sensing receptor gene are associated with clinical outcome of neuroblastoma.PloS one · 2013Article
- Article
- Article
- Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry.Carcinogenesis · 2010Article
- Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology.European journal of clinical nutrition · 2009Review
- Novel regulatory aspects of the extracellular Ca2+-sensing receptor, CaR.Pflugers Archiv : European journal of physiology · 2009Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundExperimental and epidemiologic studies have suggested that high calcium intake is associated with decreased colon cancer risk, yet very limited data are available for candidate genes in the calcium-vitamin D pathway and colon cancer risk. To address this, we evaluated whether calcium-sensing receptor (CASR) single-nucleotide polymorphisms are associated with colon cancer risk. We also examined interactions among CASR, calcium, and vitamin D intake and previously genotyped vitamin D-related genes.
methodsWe conducted a large multicenter population-based case-control study of 1,600 cases and 1,949 controls. Seventeen tagging single-nucleotide polymorphisms for CASR were selected from common single-nucleotide polymorphisms (minor allele frequency, >or=5%) based on resequencing data. Haplotypes were estimated and evaluated using HaploStats.
resultsWe did not observe an association between any CASR genotypes or haplotypes and colon cancer risk overall. However, when stratified by anatomic site, statistically significant associations were seen with risk for proximal colon cancer [rs10934578 TT: odds ratio, 1.35; 95% confidence interval (95% CI), 1.01-1.81; rs12485716 AG/AA: odds ratio, 0.84; 95% CI, 0.71-1.00; rs4678174 CT/CC: odds ratio, 0.83; 95% CI, 0.70-0.98; rs2270916 CC: odds ratio, 0.43; 95% CI, 0.19-0.97]. Concordantly, we observed a suggested association for a CASR haplotype (rs4678174, rs2270916) with risk for proximal colon cancer (global P=0.08). We did not observe any meaningful gene-environment (calcium and vitamin D) or gene-gene (CYP24A1, CYP27B1, and VDR) interactions with CASR genotypes and colon cancer risk.
conclusionOur study does not provide evidence for an overall association between CASR single-nucleotide polymorphisms and colon cancer; however, results suggest a possible role of CASR on proximal colon cancer, and subsite differences are consistent with known calcium biology. Nonetheless, these findings require confirmation.
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