ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Intrinsic conductances actively shape excitatory and inhibitory postsynaptic responses in olfactory bulb external tufted cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Dendritic synaptic integration modes under in vivo-like states.Biophysical journal · 2025Article
- Ultrastructural Contributions to Extrasynaptic Glutamatergic Signaling in Olfactory Bulb Glomeruli.The Journal of comparative neurology · 2025Article
- Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Review
- Neurotransmitter regulation rather than cell-intrinsic properties shapes the high-pass filtering properties of olfactory bulb glomeruli.The Journal of physiology · 2022Article
- CCKergic Tufted Cells Differentially Drive Two Anatomically Segregated Inhibitory Circuits in the Mouse Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The role of co-neurotransmitters in sleep and wake regulation.Molecular psychiatry · 2019Review
- Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST).Psychopharmacology · 2017Article
- The role of negative conductances in neuronal subthreshold properties and synaptic integration.Biophysical reviews · 2017Review
- Rebound from Inhibition: Self-Correction against Neurodegeneration?Journal of clinical & cellular immunology · 2017Article
- Zinc as a Neuromodulator in the Central Nervous System with a Focus on the Olfactory Bulb.Frontiers in cellular neuroscience · 2017Review
- Activation of Group II Metabotropic Glutamate Receptors Suppresses Excitability of Mouse Main Olfactory Bulb External Tufted and Mitral Cells.Frontiers in cellular neuroscience · 2017Article
- The Interglomerular Circuit Potently Inhibits Olfactory Bulb Output Neurons by Both Direct and Indirect Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Using Intrinsic Flavoprotein and NAD(P)H Imaging to Map Functional Circuitry in the Main Olfactory Bulb.PloS one · 2016Article
- Role of intraglomerular circuits in shaping temporally structured responses to naturalistic inhalation-driven sensory input to the olfactory bulb.Journal of neurophysiology · 2015Article
- Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Metabotropic glutamate receptors promote disinhibition of olfactory bulb glomeruli that scales with input strength.Journal of neurophysiology · 2015Article
- Activation of group I metabotropic glutamate receptors enhances persistent sodium current and rhythmic bursting in main olfactory bulb external tufted cells.Journal of neurophysiology · 2014Article
- Olfactory bulb short axon cell release of GABA and dopamine produces a temporally biphasic inhibition-excitation response in external tufted cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- In vivo functional properties of juxtaglomerular neurons in the mouse olfactory bulb.Frontiers in neural circuits · 2013Article
- Intraglomerular inhibition shapes the strength and temporal structure of glomerular output.Journal of neurophysiology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The initial synapse in the olfactory system is from olfactory nerve (ON) terminals to postsynaptic targets in olfactory bulb glomeruli. Recent studies have disclosed multiple presynaptic factors that regulate this important linkage, but less is known about the contribution of postsynaptic intrinsic conductances to integration at these synapses. The present study demonstrates voltage-dependent amplification of EPSPs in external tufted (ET) cells in response to monosynaptic (ON) inputs. This amplification is mainly exerted by persistent Na(+) conductance. Larger EPSPs, which bring the membrane potential to a relatively depolarized level, are further boosted by the low-voltage-activated Ca(2+) conductance. In contrast, the hyperpolarization-activated nonselective cation conductance (I(h)) attenuates EPSPs mainly by reducing EPSP duration; this also reduces temporal summation of multiple EPSPs. Regulation of EPSPs by these subthreshold, voltage-dependent conductances can enhance both the signal-to-noise ratio and the temporal summation of multiple synaptic inputs and thus help ET cells differentiate high- and low-frequency synaptic inputs. I(h) can also transform inhibitory inputs to postsynaptic excitation. When the ET cell membrane potential is relatively depolarized, as during a burst of action potentials, IPSPs produce classic inhibition. However, near resting membrane potentials where I(h) is engaged, IPSPs produce rebound bursts of action potentials. ET cells excite GABAergic PG cells. Thus, the transformation of inhibitory inputs to postsynaptic excitation in ET cells may enhance intraglomerular inhibition of mitral/tufted cells, the main output neurons in the olfactory bulb, and hence shape signaling to olfactory cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.