ArticleJournal of virology2008
Estimation of the effective number of founders that initiate an infection after aphid transmission of a multipartite plant virus.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 116 citations in OpenAlex.
- Transmission Bottleneck Size Estimation from De Novo Viral Genetic Variation.Molecular biology and evolution · 2024Article
- Nonconcomitant host-to-host transmission of multipartite virus genome segments may lead to complete genome reconstitution.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Identification of Endogenous Genes for Normalizing Titer Variation of Citrus Tristeza Virus in Aphids at Different Post-acquisition Feeding Times.The plant pathology journal · 2022Article
- Insight into aphid mediatedFrontiers in microbiology · 2022Review
- Molecular analysis of Greek isolates of cucumber mosaic virus from vegetables shows a low prevalence of satellite RNAs and suggests the presence of host-associated virus strains.Archives of virology · 2021Article
- Detection of Plant Viruses and Disease Management: Relevance of Genetic Diversity and Evolution.Frontiers in plant science · 2020Review
- Article
- Virus epidemics, plant-controlled population bottlenecks and the durability of plant resistance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Exploring the causes of small effective population sizes in cyst nematodes using artificial Globodera pallida populations.Proceedings. Biological sciences · 2019Article
- Mechanisms and Concepts in RNA Virus Population Dynamics and Evolution.Annual review of virology · 2018Review
- Small Bottleneck Size in a Highly Multipartite Virus during a Complete Infection Cycle.Journal of virology · 2018Article
- Genetic bottlenecks in intraspecies virus transmission.Current opinion in virology · 2018Review
- Transmission Bottleneck Size Estimation from Pathogen Deep-Sequencing Data, with an Application to Human Influenza A Virus.Journal of virology · 2017Article
- Multipartite viruses: adaptive trick or evolutionary treat?NPJ systems biology and applications · 2017Review
- The Strange Lifestyle of Multipartite Viruses.PLoS pathogens · 2016Review
- Genetic variation in fitness within a clonal population of a plant RNA virus.Virus evolution · 2016Article
- Epidemiological and evolutionary management of plant resistance: optimizing the deployment of cultivar mixtures in time and space in agricultural landscapes.Evolutionary applications · 2015Article
- Demographics of natural oral infection of mosquitos by Venezuelan equine encephalitis virus.Journal of virology · 2015Article
- Costs and benefits of mutational robustness in RNA viruses.Cell reports · 2014Article
- Frequency-dependent assistance as a way out of competitive exclusion between two strains of an emerging virus.Proceedings. Biological sciences · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fecundity of RNA viruses can be very high. Thus, it is often assumed that viruses have large populations, and RNA virus evolution has been mostly explained using purely deterministic models. However, population bottlenecks during the virus life cycle could result in effective population numbers being much smaller than reported censuses, and random genetic drift could be important in virus evolution. A step at which population bottlenecks may be severe is host-to-host transmission. We report here an estimate of the size of the population that starts a new infection when Cucumber mosaic virus (CMV) is transmitted by the aphid Aphis gossypii, based on the segregation of two CMV genotypes in plants infected by aphids that acquired the virus from plants infected by both genotypes. Results show very small effective numbers of founders, between one and two, both in experiments in which the three-partite genome of CMV was aphid transmitted and in experiments in which a fourth RNA, CMV satellite RNA, was also transmitted. These numbers are very similar to those published for Potato virus Y, which has a monopartite genome and is transmitted by aphids according to a different mechanism than CMV. Thus, the number of genomic segments seems not to be a major determinant of the effective number of founders. Also, our results suggest that the occurrence of severe bottlenecks during horizontal transmission is general for viruses nonpersistently transmitted by aphids, indicating that random genetic drift should be considered when modeling virus evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.