ArticleNucleic acids research2009
TMFunction: database for functional residues in membrane proteins.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Identification of genotypic variants and its proteomic mutations of Brazilian SARS-CoV-2 isolates.Virus research · 2022Article
- Development of a machine learning method to predict membrane protein-ligand binding residues using basic sequence information.Advances in bioinformatics · 2015Article
- PDBTM: Protein Data Bank of transmembrane proteins after 8 years.Nucleic acids research · 2013Article
- Predicting protein-ATP binding sites from primary sequence through fusing bi-profile sampling of multi-view features.BMC bioinformatics · 2012Article
- Relationship between amino acid properties and functional parameters in olfactory receptors and discrimination of mutants with enhanced specificity.BMC bioinformatics · 2012Article
- Real value prediction of protein folding rate change upon point mutation.Journal of computer-aided molecular design · 2012Article
- OMPdb: a database of {beta}-barrel outer membrane proteins from Gram-negative bacteria.Nucleic acids research · 2011Article
- MeMotif: a database of linear motifs in alpha-helical transmembrane proteins.Nucleic acids research · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have developed the database TMFunction, which is a collection of more than 2900 experimentally observed functional residues in membrane proteins. Each entry includes the numerical values for the parameters IC50 (measure of the effectiveness of a compound in inhibiting biological function), V(max) (maximal velocity of transport), relative activity of mutants with respect to wild-type protein, binding affinity, dissociation constant, etc., which are important for understanding the sequence-structure-function relationship of membrane proteins. In addition, we have provided information about name and source of the protein, Uniprot and Protein Data Bank codes, mutational and literature information. Furthermore, TMFunction is linked to related databases and other resources. We have set up a web interface with different search and display options so that users have the ability to get the data in several ways. TMFunction is freely available at http://tmbeta-genome.cbrc.jp/TMFunction/.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.