ArticleBMC microbiology2008
Sulphur metabolism and cellulase gene expression are connected processes in the filamentous fungus Hypocrea jecorina (anamorph Trichoderma reesei).
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Transcriptome Analysis ofJournal of fungi (Basel, Switzerland) · 2023Article
- Ammonium Ions Induce Cellulase Synthesis in Trichoderma koningii.Current microbiology · 2021Article
- Effects of Essential Oil Citral on the Growth, Mycotoxin Biosynthesis and Transcriptomic Profile ofToxins · 2019Article
- Broad Substrate-Specific Phosphorylation Events Are Associated With the Initial Stage of Plant Cell Wall Recognition inFrontiers in microbiology · 2019Article
- The Promoter Toolbox for Recombinant Gene Expression inFrontiers in bioengineering and biotechnology · 2018Review
- Regulation of plant cell wall degradation by light inFungal biology and biotechnology · 2018Review
- Histone Deacetylase HDA-2 Regulates Trichoderma atroviride Growth, Conidiation, Blue Light Perception, and Oxidative Stress Responses.Applied and environmental microbiology · 2017Article
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- Genome wide analysis of protein production load in Trichoderma reesei.Biotechnology for biofuels · 2016Article
- Deciphering the signaling mechanisms of the plant cell wall degradation machinery in Aspergillus oryzae.BMC systems biology · 2015Article
- L-Methionine repressible promoters for tuneable gene expression in Trichoderma reesei.Microbial cell factories · 2015Article
- VIB1, a link between glucose signaling and carbon catabolite repression, is essential for plant cell wall degradation by Neurospora crassa.PLoS genetics · 2014Article
- Crossroads between light response and nutrient signalling: ENV1 and PhLP1 act as mutual regulatory pair in Trichoderma reesei.BMC genomics · 2014Article
- Targets of light signalling in Trichoderma reesei.BMC genomics · 2013Article
- Regulation of cellulase and hemicellulase gene expression in fungi.Current genomics · 2013Article
- Unravelling the molecular basis for light modulated cellulase gene expression - the role of photoreceptors in Neurospora crassa.BMC genomics · 2012Article
- The phosducin-like protein PhLP1 impacts regulation of glycoside hydrolases and light response in Trichoderma reesei.BMC genomics · 2011Article
- Dehydrogenase GRD1 represents a novel component of the cellulase regulon in Trichoderma reesei (Hypocrea jecorina).Applied and environmental microbiology · 2011Article
- The effects of disruption of phosphoglucose isomerase gene on carbon utilisation and cellulase production in Trichoderma reesei Rut-C30.Microbial cell factories · 2011Article
- Relevance of the light signaling machinery for cellulase expression in Trichoderma reesei (Hypocrea jecorina).BMC research notes · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSulphur compounds like cysteine, methionine and S-adenosylmethionine are essential for the viability of most cells. Thus many organisms have developed a complex regulatory circuit that governs the expression of enzymes involved in sulphur assimilation and metabolism. In the filamentous fungus Hypocrea jecorina (anamorph Trichoderma reesei) little is known about the participants in this circuit.
resultsAnalyses of proteins binding to the cellulase activating element (CAE) within the promotor of the cellobiohydrolase cbh2 gene led to the identification of a putative E3 ubiquitin ligase protein named LIMPET (LIM1), which is an orthologue of the sulphur regulators SCON-2 of Neurospora crassa and Met30p of Saccharomyces cerevisiae. Transcription of lim1 is specifically up-regulated upon sulphur limitation and responds to cellulase inducing conditions. In addition, light dependent stimulation/shut down of cellulase gene transcription by methionine in the presence of sulphate was observed. Further, lim1 transcriptionally reacts to a switch from constant darkness to constant light and is subject to regulation by the light regulatory protein ENVOY. Thus lim1, despite its function in sulphur metabolite repression, responds both to light as well as sulphur- and carbon source. Upon growth on cellulose, the uptake of sulphate is dependent on the light status and essential for growth in light. Unlike other fungi, growth of H. jecorina is not inhibited by selenate under low sulphur conditions, suggesting altered regulation of sulphur metabolism. Phylogenetic analysis of the five sulphate permeases found in the genome of H. jecorina revealed that the predominantly mycelial sulphate permease is lacking, thus supporting this hypothesis.
conclusionOur data indicate that the significance of the sulphate/methionine-related signal with respect to cellulase gene expression is dependent on the light status and reaches beyond detection of sulphur availability.
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