ReviewMolecular biotechnology2009
Allelic association: linkage disequilibrium structure and gene mapping.
Review in Molecular biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Association of circulating leptin concentration with the risk of Clostridium difficile colitis and exploration of their associated mediators: A mendelian randomisation study.Journal, genetic engineering & biotechnology · 2026Article
- Analysis of spermidine's effect on coronary heart disease risk using bidirectional Mendelian randomization and LC-MS/MS.Hereditas · 2025Article
- The association between serum 25-hydroxyvitamin D levels and erectile dysfunction: a two-sample Mendelian randomization analysis.International journal of impotence research · 2024Article
- Interaction between systemic iron parameters and left ventricular structure and function in the preserved ejection fraction population: a two-sample bidirectional Mendelian randomization study.Journal of geriatric cardiology : JGC · 2024Article
- Relationship between inflammatory bowel disease and erectile dysfunction: a 2-sample Mendelian randomization study.Sexual medicine · 2023Article
- Benchmarking RNA Editing Detection Tools.Biotech (Basel (Switzerland)) · 2023Review
- Exploring the Causality Between Hypothyroidism and Non-alcoholic Fatty Liver: A Mendelian Randomization Study.Frontiers in cell and developmental biology · 2021Article
- Causal Association Between Heart Failure and Alzheimer's Disease: A Two-Sample Bidirectional Mendelian Randomization Study.Frontiers in genetics · 2021Article
- Article
- Single-nucleotide polymorphisms associated with skin naphthyl-keratin adduct levels in workers exposed to naphthalene.Environmental health perspectives · 2012Article
- The Genetic Diversity and Structure of Linkage Disequilibrium of the MTHFR Gene in Populations of Northern Eurasia.Acta naturae · 2012Article
- The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus.Nature reviews. Nephrology · 2011Review
- Serum 25-hydroxyvitamin D levels and the risk of non-alcoholic fatty liver: A two-sample Mendelian randomization study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The linkage disequilibrium (LD) structure of the human genome is now well understood and characterised for a number of human populations. The LD structure underpins the design and execution of candidate gene and genome-wide association mapping studies. Successful association mapping studies completed to date provide vital new insights into the genetic influences on common diseases, such as diabetes, some cancers and heart disease. The LD structure also presents new avenues of research into the genetic history of human populations, the effects of natural selection and the impact of recombination on the genomic landscape. This review introduces this exciting and complex field by encompassing this range of topics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.