ReviewNeurochemical research2009
Dopamine and aging: intersecting facets.
Review in Neurochemical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Parallel Gene Expression Changes in Ventral Midbrain Dopamine and GABA Neurons during Normal Aging.eNeuro · 2025Article
- Impact of aging on the central and enteric nervous system in a Parkinson's disease mouse model.Frontiers in aging neuroscience · 2025Article
- [Androgens and Parkinson's disease: the role in humans and in experiment].Problemy endokrinologii · 2022Review
- Dopamine D1 receptor in the NAc shell is involved in delayed emergence from isoflurane anesthesia in aged mice.Brain and behavior · 2021Article
- Androgens and Parkinson's Disease: A Review of Human Studies and Animal Models.Androgens: clinical research and therapeutics · 2021Review
- Dopamine: an immune transmitter.Neural regeneration research · 2020Review
- Transcription Factors Phox2a/2b Upregulate Expression of Noradrenergic and Dopaminergic Phenotypes in Aged Rat Brains.Neurotoxicity research · 2020Article
- Loss of Sensitivity to Rewards by Dopamine Neurons May Underlie Age-Related Increased Probability Discounting.Frontiers in aging neuroscience · 2020Article
- The Effects of Age, from Young to Middle Adulthood, and Gender on Resting State Functional Connectivity of the Dopaminergic Midbrain.Frontiers in human neuroscience · 2017Article
- Comparing the effects of food restriction and overeating on brain reward systems.Experimental gerontology · 2013Review
- A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice.Age (Dordrecht, Netherlands) · 2013Article
- Article
- Functional and evolutionary trade-offs co-occur between two consolidated memory phases in Drosophila melanogaster.Proceedings. Biological sciences · 2012Article
- Variation in genes involved in dopamine clearance influence the startle response in older adults.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
- Between destiny and disease: genetics and molecular pathways of human central nervous system aging.Progress in neurobiology · 2011Review
- Article
- Aging and the Mammalian regulatory triumvirate.Aging and disease · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging encompasses life itself so understanding requires frameworks that forge unity amidst complexity. The free radical theory of aging is one example. The original focus on damage was augmented recently by appreciation that reactive oxygen and nitrogen species are essential to normal signaling and cell function. This paradigm is currently undergoing an explosive expansion fueled by the discovery that regulatory organization is a merry-go-round of redox cycling seamlessly fused to endogenous clocks. This might best be described as an "Electroplasmic Cycle." This is certainly applicable to dopaminergic neurons with their exceptional metabolic, electrical and rhythmic properties. Here I review normal aging of dopamine systems to highlight them as a valuable model. I then examine the possible integration of free radical and ion channel theories of aging. Finally, I incorporate clocks and explore the multifaceted implications of electroplasmic cycles with special emphasis on dopamine.
Indexed as
Identifiers
18841466What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.