ArticleBritish journal of cancer2008
Increased prevalence of testicular microlithiasis in men with familial testicular cancer and their relatives.
Article in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Incidence characteristics of testicular microlithiasis and its association with risk of primary testicular tumors in children: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2020Pooled it
- Testicular microlithiasis and testicular cancer: review of the literature.International urology and nephrology · 2016Pooled it
- Testicular microlithiasis imaging and follow-up: guidelines of the ESUR scrotal imaging subcommittee.European radiology · 2015Guideline
- Clinical and imaging diagnosis of pediatric testicular microlithiasis: a physician's dilemma.Frontiers in pediatrics · 2025Review
- Article
- Lack of pathogenic germline DICER1 variants in males with testicular germ-cell tumors.Cancer genetics · 2020Article
- Association between risk factors and testicular microlithiasis.Acta radiologica open · 2019Article
- Testicular microlithiasis and testicular tumor: a review of the literature.Basic and clinical andrology · 2018Article
- Mosaic chromosome Y loss and testicular germ cell tumor risk.Journal of human genetics · 2017Article
- Testicular Microlithiasis: Patient Compliance in a Two-Year Follow-Up Program.Ultrasound international open · 2016Article
- Prospectively Identified Incident Testicular Cancer Risk in a Familial Testicular Cancer Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Advances in the treatment of testicular cancer.Translational andrology and urology · 2015Review
- Familial testicular germ cell tumor: no associated syndromic pattern identified.Hereditary cancer in clinical practice · 2014Article
- Close ties: an exploratory Colored Eco-Genetic Relationship Map (CEGRM) study of social connections of men in Familial Testicular Cancer (FTC) families.Hereditary cancer in clinical practice · 2012Article
- Promoter methylation of candidate genes associated with familial testicular cancer.International journal of molecular epidemiology and genetics · 2012Article
- Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour.Journal of medical genetics · 2011Article
- Testicular microlithiasis: recent advances in understanding and management.Nature reviews. Urology · 2011Review
- Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotype.Endocrine-related cancer · 2010Review
- Familial testicular germ cell tumours.Best practice & research. Clinical endocrinology & metabolism · 2010Review
- LINE-1 methylation is inherited in familial testicular cancer kindreds.BMC medical genetics · 2010Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Testicular germ cell tumours (TGCT) cluster in families, but responsible genes remain unidentified. The association between testicular microlithiasis (TM) and testicular carcinoma in situ (CIS) suggests that TM may be a TC risk factor. We report testicular ultrasound findings in men with familial TGCT (FTGCT) and their unaffected relatives. A total of 81 men (48 affected and 33 unaffected) from 31 families with > or =2 TC cases underwent testicular ultrasound. Testicular microlithiasis was defined as either 'classic' (> or =5 microliths) or 'limited' (<5 microliths). Statistical analyses used Fisher's exact test and permutation testing. Testicular microlithiasis was more frequent in the contralateral testicles of men with a history of TGCT (affected men) than in unaffected men (48 vs 24%, P=0.04). The association appeared stronger for classic TM (21 vs 9%) than for limited TM (27 vs 15%). Testicular microlithiases were bilateral in six out of seven (87%) unaffected men. Among affected men, TM was not associated with histology, age at diagnosis or cancer treatment. Of the 31 families, 10 accounted for a majority (61%) of the TM cases identified (P=0.11). Testicular microlithiasis was more prevalent among FTGCT family members than described previously in the general population, and was more common among FTGCT cases vs unaffected blood relatives. Testicular microlithiasis appeared to cluster in certain families. These findings suggest both a familial predisposition to TM and an association between TM and FTGCT. If proven, this could be clinically important to men in FTGCT families, and may be useful in identifying specific genes involved in FTGCT.
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