ArticleProceedings of the National Academy of Sciences of the United States of America2008
Anisotropic rheology and directional mechanotransduction in vascular endothelial cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Early committed polarization of intracellular tension in response to cell shape determines the osteogenic differentiation of mesenchymal stromal cells.Acta biomaterialia · 2023Article
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Biomimetic Hydrogels in the Study of Cancer Mechanobiology: Overview, Biomedical Applications, and Future Perspectives.Gels (Basel, Switzerland) · 2022Review
- Angiogenesis in Free-Standing Two-Vasculature-Embedded Scaffold Extruded by Two-Core Laminar Flow Device.International journal of bioprinting · 2022Article
- The microRNA-210-Stathmin1 Axis Decreases Cell Stiffness to Facilitate the Invasiveness of Colorectal Cancer Stem Cells.Cancers · 2021Article
- METTL3-dependent NProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Experimental and theoretical energetics of walking molecular motors under fluctuating environments.Biophysical reviews · 2020Review
- Endothelial mechanobiology.APL bioengineering · 2020Article
- Anisotropy vs isotropy in living cell indentation with AFM.Scientific reports · 2019Article
- Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread.Scientific reports · 2018Article
- Epithelial-mesenchymal transition softens head and neck cancer cells to facilitate migration in 3D environments.Journal of cellular and molecular medicine · 2018Article
- Review of Cellular Mechanotransduction.Journal of physics D: Applied physics · 2017Article
- Integrated Analysis of Intracellular Dynamics of MenaINV Cancer Cells in a 3D Matrix.Biophysical journal · 2017Article
- Rat Liver Enzyme Release Depends on Blood Flow-Bearing Physical Forces Acting in Endothelium Glycocalyx rather than on Liver Damage.Oxidative medicine and cellular longevity · 2017Article
- Mechanical plasticity of cells.Nature materials · 2016Article
- Bio- chemical and physical characterizations of mesenchymal stromal cells along the time course of directed differentiation.Scientific reports · 2016Article
- Two-point particle tracking microrheology of nematic complex fluids.Soft matter · 2016Article
- Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics.Journal of biomechanical engineering · 2016Review
- β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration.Journal of cellular and molecular medicine · 2015Article
- Stem cells rejuvenate radiation-impaired vasculogenesis in murine distraction osteogenesis.Plastic and reconstructive surgery · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Adherent cells remodel their cytoskeleton, including its directionality, in response to directional mechanical stimuli with consequent redistribution of intracellular forces and modulation of cell function. We analyzed the temporal and spatial changes in magnitude and directionality of the cytoplasmic creep compliance (Gamma) in confluent cultures of bovine aortic endothelial cells subjected to continuous laminar flow shear stresses. We extended particle tracking microrheology to determine at each point in the cytoplasm the principal directions along which Gamma is maximal and minimal. Under static condition, the cells have polygonal shapes without specific alignment. Although Gamma of each cell exhibits directionality with varying principal directions, Gamma averaged over the whole cell population is isotropic. After continuous laminar flow shear stresses, all cells gradually elongate and the directions of maximal and minimal Gamma become, respectively, parallel and perpendicular to flow direction. This mechanical alignment is accompanied by a transition of the cytoplasm to be more fluid-like along the flow direction and more solid-like along the perpendicular direction; at the same time Gamma increases at the downstream part of the cells. The resulting directional anisotropy and spatial inhomogeneity of cytoplasmic rheology may play an important role in mechanotransduction in adherent cells by providing a means to sense the direction of mechanical stimuli.
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