ArticleGene2008
Differential selective pressures on the merozoite surface protein 2 locus of Plasmodium falciparum in a low endemic area.
Article in Gene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Genetic Diversity and Phylogenetic Relatedness of Cameroonian Plasmodium falciparum Isolates and Comparative Analysis with Global Populations.Acta parasitologica · 2025Article
- Naturally acquired IgG responses toFrontiers in immunology · 2024Article
- A genomic platform for surveillance and antigen discovery in Plasmodium spp. using long-read amplicon sequencing.Cell reports methods · 2023Article
- Analysis of sequence diversity in Plasmodium falciparum glutamic acid-rich protein (PfGARP), an asexual blood stage vaccine candidate.Scientific reports · 2023Article
- Article
- Conformational dynamics and antigenicity in the disordered malaria antigen merozoite surface protein 2.PloS one · 2015Article
- Plasmodium falciparum populations from northeastern Myanmar display high levels of genetic diversity at multiple antigenic loci.Acta tropica · 2013Article
- Genetic variation in the Plasmodium falciparum circumsporozoite protein in India and its relevance to RTS,S malaria vaccine.PloS one · 2012Article
- Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome.Molecular biology and evolution · 2010Article
- Bottleneck effects on vaccine-candidate antigen diversity of malaria parasites in Thailand.Vaccine · 2010Article
- Nucleotide sequence polymorphism at the apical membrane antigen-1 locus reveals population history of Plasmodium vivax in Thailand.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2009Article
- Natural selection maintains a stable polymorphism at the circumsporozoite protein locus of Plasmodium falciparum in a low endemic area.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2009Article
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3 authors.
Funding
Abstract
195 Plasmodium falciparum merozoite surface protein-2 alleles collected in Tak Province, Thailand, in 1996 and 2006 revealed extremely limited sequence polymorphism except in the variable (V) region, which defines the two allelic families 3D7 and FC27. This pattern is most easily explained by repeated inter-allelic gene conversion events homogenizing alleles outside the V region. Comparison of synonymous and nonsynonymous differences in V regions within allelic families supported the hypothesis that amino acid sequence polymorphism in this region is selectively favored. The pattern of sequence differentiation supported the hypothesis that repeats in the V region have evolved by concerted evolution in the 3D7 family but not in the FC27 family. In the FC27 family two alleles of relatively high frequency were the most common V-region alleles in both 1996 and 2006, while 3D7 alleles constituted a significantly greater proportion of the sequences collected in 2006 (56.1%) than of those collected in 1996 (28.9%). These changes in the frequencies of 3D7 alleles may reflect increased intensity of selection on the P. falciparum population in Thailand as a result of effective control measures that have sharply reduced the incidence of malaria infection.
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