ArticleBMC genetics2008
A genome-wide scan for quantitative trait loci affecting limb bone lengths and areal bone mineral density of the distal femur in a White Duroc x Erhualian F2 population.
Article in BMC genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Unravelling novel and pleiotropic genes for cannon bone circumference and bone mineral density in Yorkshire pigs.Journal of animal science · 2024Pooled it
- A meta analysis of genome-wide association studies for limb bone lengths in four pig populations.BMC genetics · 2015Pooled it
- Genome-Wide Association Study for Somatic Skeletal Traits in Duroc × (Landrace × Yorkshire) Pigs.Animals : an open access journal from MDPI · 2023Article
- Whole-genome resequencing reveals candidate mutations for pig prolificacy.Proceedings. Biological sciences · 2017Article
- A systems genetics study of swine illustrates mechanisms underlying human phenotypic traits.BMC genomics · 2015Article
- A genome-wide association study of limb bone length using a Large White × Minzhu intercross population.Genetics, selection, evolution : GSE · 2014Article
- KRT8, FAF1 and PTH1R gene polymorphisms are associated with leg weakness traits in pigs.Molecular biology reports · 2013Article
- The G32E functional variant reduces activity of PPARD by nuclear export and post-translational modification in pigs.PloS one · 2013Article
- A comprehensive survey of copy number variation in 18 diverse pig populations and identification of candidate copy number variable genes associated with complex traits.BMC genomics · 2012Article
- A missense mutation in PPARD causes a major QTL effect on ear size in pigs.PLoS genetics · 2011Article
- Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population.Genetics, selection, evolution : GSE · 2011Article
- Review
- A genome-wide scan for quantitative trait loci affecting serum glucose and lipids in a White Duroc x Erhualian intercross F(2) population.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimb bone lengths and bone mineral density (BMD) have been used to assess the bone growth and the risk of bone fractures in pigs, respectively. It has been suggested that limb bone lengths and BMD are under genetic control. However, the knowledge about the genetic basis of the limb bone lengths and mineralisatinon is limited in pigs. The aim of this study was to identify quantitative trait loci (QTL) affecting limb bone lengths and BMD of the distal femur in a White Duroc x Erhualian resource population.
resultsLimb bone lengths and femoral bone mineral density (fBMD) were measured in a total of 1021 and 116 F2 animals, respectively. There were strong positive correlations among the lengths of limb bones and medium positive correlations between the lengths of limb bones and fBMD. A whole-genome scan involving 183 microsatellite markers across the pig genome revealed 35 QTL for the limb bone lengths and 2 for femoral BMD. The most significant QTL for the lengths of five limb bones were mapped on two chromosomes affecting all 5 limb bones traits. One was detected around 57 cM on pig chromosome (SSC) 7 with the largest F-value of more than 26 and 95% confidence intervals of less than 5 cM, providing a crucial start point to identify the causal genes for these traits. The Erhualian alleles were associated with longer limb bones. The other was located on SSCX with a peak at 50-53 cM, whereas alleles from the White Duroc breed increased the bone length. Many QTL identified are homologous to the human genomic regions containing QTL for bone-related traits and a list of interesting candidate genes.
conclusionThis study detected the QTL for the lengths of scapula, ulna, humerus and tibia and fBMD in the pig for the first time. Moreover, several new QTL for the pig femoral length were found. As correlated traits, QTL for the lengths of five limb bones were mainly located in the same genomic regions. The most promising QTL for the lengths of five limb bones on SSC7 merits further investigation.
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