ArticleBMC cancer2008
Nuclear hBD-1 accumulation in malignant salivary gland tumours.
Article in BMC cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Prognostic significance of p53 immunohistochemical expression in adenoid cystic carcinoma of the salivary glands: a meta-analysis.Oncotarget · 2017Pooled it
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- Update on antimicrobial peptides: key elements inThe Journal of general virology · 2025Review
- Role of innate host defense proteins in oral cancerogenesis.Periodontology 2000 · 2024Review
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- Discovery and mechanisms of host defense to oncogenesis: targeting the β-defensin-1 peptide as a natural tumor inhibitor.Cancer biology & therapy · 2019Article
- A Review of Selected Factors of Salivary Gland Tumour Formation and Malignant Transformation.BioMed research international · 2018Review
- Alarmins and immunity.Immunological reviews · 2017Review
- Oral pathogens change proliferation properties of oral tumor cells by affecting gene expression of human defensins.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Oncogenic relevant defensins: expression pattern and proliferation characteristics of human tumor cell lines.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Human α-defensin (DEFA) gene expression helps to characterise benign and malignant salivary gland tumours.BMC cancer · 2012Article
- Immunohistochemical localization of beta defensins in the endometrium of rat uterus during the postpartum involution period.Veterinary research communications · 2012Article
- The yin and yang of human Beta-defensins in health and disease.Frontiers in immunology · 2012Article
- Beta-defensins: what are they really doing in the oral cavity?Oral diseases · 2011Review
- Increased human defensine levels hint at an inflammatory etiology of bisphosphonate-associated osteonecrosis of the jaw: an immunohistological study.Journal of translational medicine · 2011Article
- Defensins as anti-inflammatory compounds and mucosal adjuvants.Future microbiology · 2010Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription and induction of apoptosis in malignant epithelial tumours. Therefore this study was conducted to characterise proteins involved in cell cycle control and host defence in different benign and malignant salivary gland tumours in comparison with healthy salivary gland tissue.
methods21 paraffin-embedded tissue samples of benign (n = 7), and malignant (n = 7) salivary gland tumours as well as healthy (n = 7) salivary glands were examined immunohistochemically for the expression of p53, bcl-2, and hBD-1, -2, -3.
resultsHBD-1 was distributed in the cytoplasm of healthy salivary glands and benign salivary gland tumours but seems to migrate into the nucleus of malignant salivary gland tumours. Pleomorphic adenomas showed cytoplasmic as well as weak nuclear hBD-1 staining.
conclusionHBD-1, 2 and 3 are traceable in healthy salivary gland tissue as well as in benign and malignant salivary gland tumours. As hBD-1 is shifted from the cytoplasm to the nucleus in malignant salivary gland tumours, we hypothesize that it might play a role in the oncogenesis of these tumours. In pleomorphic adenomas hBD-1 might be connected to their biologic behaviour of recurrence and malignant transformation.
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