ArticleThe Journal of comparative neurology2008
Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice.
Article in The Journal of comparative neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 29 citations in OpenAlex.
- Transcriptional profiling of dental sensory and proprioceptive trigeminal neurons using single-cell RNA sequencing.International journal of oral science · 2023Article
- Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.Matrix biology : journal of the International Society for Matrix Biology · 2021Article
- The function of heparan sulfate during branching morphogenesis.Matrix biology : journal of the International Society for Matrix Biology · 2017Review
- Expanding the 3-O-Sulfate Proteome--Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity.ACS chemical biology · 2016Article
- Dynamic expression of transcription factor Brn3b during mouse cranial nerve development.The Journal of comparative neurology · 2016Article
- Mammalian touch catches up.Current opinion in neurobiology · 2015Review
- Hs3st3-modified heparan sulfate controls KIT+ progenitor expansion by regulating 3-O-sulfotransferases.Developmental cell · 2014Article
- Heparan sulfate 3-O-sulfation: a rare modification in search of a function.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- The organization of submodality-specific touch afferent inputs in the vibrissa column.Cell reports · 2013Article
- Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2013Article
- Signals and switches in Mammalian neural crest cell differentiation.Cold Spring Harbor perspectives in biology · 2013Review
- N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland.The Journal of biological chemistry · 2012Article
- Differential expression of components of the retinoic acid signaling pathway in the adult mouse olfactory epithelium.The Journal of comparative neurology · 2012Article
- Article
- Intersectional Cre driver lines generated using split-intein mediated split-Cre reconstitution.Scientific reports · 2012Article
- Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.Developmental biology · 2011Article
- Heparan sulfate proteoglycans.Cold Spring Harbor perspectives in biology · 2011Review
- Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Expression of pax6 and sox2 in adult olfactory epithelium.The Journal of comparative neurology · 2010Article
- The cell biology of touch.The Journal of cell biology · 2010Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Somatosensory neurons are classified into three main types according to their modalities: nociceptive, thermal, and mechanosensory. Within each modality group, neurons can be further divided into morphologically and functionally distinct subclasses. Here we show that heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 (HS3ST-2) is a marker for specific subsets of TrkC-expressing cutaneous low-threshold mechanosensory and proprioceptive mechanosensory neurons. Two-color in situ analysis revealed that almost all HS3ST-2 signals colocalized with TrkC but not with TrkA or TrkB mRNA. To visualize the morphological subtypes of HS3ST-2/TrkC-expressing neurons, we generated a HS3ST-2-hPLAP knock-in mouse line, in which HS3ST-2-expressing neurons and their projections are labeled by human placental alkaline phosphatase (hPLAP). AP staining in these mice demonstrated that sensory endings of muscle spindles and Golgi tendon organs as well as the cutaneous mechanosensory Merkel and longitudinal lanceolate endings in the whiskers are strongly positive for hPLAP activity. In contrast, no nociceptive endings are labeled. In the glabrous and hairy skin, rare Merkel endings and transverse lanceolate endings are weakly stained. During development, each type of nerve endings forms at different time point. Muscle innervations differentiate first, followed by formation of cutaneous sensory endings. Our results revealed the subtype identities of TrkC-positive mechanosensory neurons and demonstrated the usefulness of HS3ST-2 as a genetic marker for these subclasses of neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.