ReviewPediatric nephrology (Berlin, Germany)2009
Measuring glomerular filtration rate in children; can cystatin C replace established methods? A review.
Review in Pediatric nephrology (Berlin, Germany), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Pharmacokinetic properties of conventional and double-dose sulfadoxine-pyrimethamine given as intermittent preventive treatment in infancy.Antimicrobial agents and chemotherapy · 2011Trial
- Association of albuminuria with kidney function and hemodynamic disturbance in pre-school children who undergo congenital heart disease surgery.Pediatric nephrology (Berlin, Germany) · 2024Article
- Role of foetal kidney size on kidney function in childhood: the born in bradford cohort renal study.BMC nephrology · 2023Article
- ESTIMATION OF THE GLOMERULAR FILTRATION RATE IN CHILDREN WITH HEMOPHILIA.Acta clinica Croatica · 2022Article
- Population Pharmacokinetics of Unbound and Total Teicoplanin in Critically Ill Pediatric Patients.Clinical pharmacokinetics · 2021Observational
- Obesity Facts and Their Influence on Renal Function Across the Life Span.Frontiers in medicine · 2021Review
- Prenatal alcohol exposure affects renal function in overweight schoolchildren: birth cohort analysis.Pediatric nephrology (Berlin, Germany) · 2020Article
- Cystatin C serum levels in healthy children are related to age, gender, and pubertal stage.Pediatric nephrology (Berlin, Germany) · 2019Article
- Measurement and Estimation of Glomerular Filtration Rate in Children.Advances in chronic kidney disease · 2017Review
- Prospective analysis of long-term renal function in survivors of childhood Wilms tumor.Pediatric nephrology (Berlin, Germany) · 2017Article
- Change of cystatin C values in preterm infants with asphyxia-From two centers of China.Journal of clinical laboratory analysis · 2017Article
- Arterial Switch Operation and Plasma Biomarkers: Analysis and Correlation with Early Postoperative Outcomes.Pediatric cardiology · 2017Article
- Fetal first trimester growth is not associated with kidney outcomes in childhood.Pediatric nephrology (Berlin, Germany) · 2017Article
- Measuring and estimating glomerular filtration rate in children.Pediatric nephrology (Berlin, Germany) · 2017Article
- Article
- No Impact of the Analytical Method Used for Determining Cystatin C on Estimating Glomerular Filtration Rate in Children.Frontiers in pediatrics · 2017Article
- Childhood Estimates of Glomerular Filtration Rate Based on Creatinine and Cystatin C: Importance of Body Composition.American journal of nephrology · 2017Article
- Are low birth weight neonates at risk for suboptimal renal growth and function during infancy?BMC nephrology · 2016Article
- The impact of estimated glomerular filtration rate equations on chronic kidney disease staging in pediatric renal or heart transplant recipients.Pediatric nephrology (Berlin, Germany) · 2016Article
- Correlation of cystatin C and creatinine based estimates of renal function in children with hydronephrosis.Journal of renal injury prevention · 2016Article
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim was to evaluate published methods that use serum cystatin C (s-CysC) for measuring glomerular filtration rate (GFR) in children and to discuss advantages and limitations of s-CysC and of established GFR methods. A comprehensive literature review of clinical studies in children evaluating s-CysC or CysC-based formulas and plasma creatinine or creatinine-based formulas against an exogenous reference method using receiver operating characteristics (ROC) curves or Bland-Altman plots is presented. The comparison of s-CysC with plasma creatinine indicated that s-CysC was superior to plasma creatinine in five of 13 studies; four studies showed no difference, and, in four studies, no statistical comparison was made. Comparison of s-CysC and the Schwartz formula showed that s-CysC was superior to the Schwartz formula in two of seven studies; two studies demonstrated no difference, and, in one study, the Schwartz formula was superior to s-CysC. In two studies no statistical comparison was made. The CysC-based prediction equations all had high accuracy but low agreement when compared with a reference GFR, in the range of 30-40% at best. S-CysC is most likely superior to plasma creatinine and at least equal to creatinine-based formulas. CysC-based prediction equations are at least as good as creatinine-based formulas but cannot replace exogenous methods.
Indexed as
Identifiers
18839216What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.