ArticleInternational journal of legal medicine2009
Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry.
Article in International journal of legal medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Thinking beyond blood: brain concentrations and brain-blood ratios in postmortem toxicology.Journal of analytical toxicology · 2026Article
- From blood to brain: postmortem brain concentrations and brain-blood ratios of chlorprothixene, clozapine, olanzapine, and quetiapine.Journal of analytical toxicology · 2026Article
- Brain concentrations and brain-blood ratios of amitriptyline and nortriptyline in forensic postmortem cases.Journal of analytical toxicology · 2025Article
- A Systematic Review of Metabolite-to-Drug Ratios of Pharmaceuticals in Hair for Forensic Investigations.Metabolites · 2021Review
- Determination of Antidepressants and Antipsychotics in Dried Blood Spots (DBSs) Collected from Post-Mortem Samples and Evaluation of the Stability over a Three-Month Period.Molecules (Basel, Switzerland) · 2019Article
- Sertraline demonstrates fungicidal activityMycology · 2016Article
- Separation of positional CPP isomers by chiral HPLC-DAD of seized tablets.International journal of legal medicine · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A gas chromatographic-mass spectrometric (GC-MS) method in positive ion chemical ionization mode in combination with a solid phase extraction was optimized for new-generation antidepressants and their metabolites in postmortem blood, brain tissue, and hair. Twelve antidepressants and their active metabolites (i.e., mirtazapine, viloxazine, venlafaxine, citalopram, mianserin, reboxetine, fluoxetine, fluvoxamine, sertraline, maprotiline, melitracen, paroxetine, desmethylfluoxetine, desmethylmianserin, desmethylmirtazapine, desmethylsertraline, desmethylmaprotiline, desmethylcitalopram, and didesmethylcitalopram) could be quantified. In this article, in addition to the validation of the GC-MS method, four postmortem cases are discussed to demonstrate the usefulness of the described method in forensic toxicology. In these cases, sertraline, fluoxetine, citalopram, and trazodone in combination with their active metabolites were quantified. Blood concentrations ranged from subtherapeutic to toxic concentrations, while brain to plasma ratios ranged from 0.8 to 17. Hair concentrations ranged from 0.4 to 2.5 ng/mg depending on the compound and hair segment.
Indexed as
Identifiers
18839201What OpenQuestion holds
Registered trials
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