Once is not enough: clinical trials in sepsis.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2009
   Pooled it
2. How the context of reception affects the meaning of RCT evidence.Health (London, England : 1997) · 2024
   Trial
3. Anakinra authorized to treat severe coronavirus disease 2019; Sepsis breakthrough or time to reflect?Frontiers in microbiology · 2023
   Article
4. KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.JCI insight · 2019
   Article
5. Haptoglobin improves shock, lung injury, and survival in canine pneumonia.JCI insight · 2018
   Article
6. Concordance of renal stone culture: PMUC, RPUC, RSC and post-PCNL sepsis-a non-randomized prospective observation cohort study.International urology and nephrology · 2017
   Observational
7. Research as a Standard of Care in the PICU.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2016
   Review
8. The impact of cardiac dysfunction on acute respiratory distress syndrome and mortality in mechanically ventilated patients with severe sepsis and septic shock: an observational study.Journal of critical care · 2015
   Observational
9. Redox state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis.Molecular & cellular proteomics : MCP · 2014
   Observational
10. Role of biphasic changes in splenic dendritic cell activity in a mouse model of multiple organ dysfunction syndrome.International journal of clinical and experimental pathology · 2014
    Article
11. Targeting F box protein Fbxo3 to control cytokine-driven inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2013
    Article
12. Risk factors for sepsis after percutaneous renal stone surgery.Nature reviews. Urology · 2013
    Review
13. Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors.Antimicrobial agents and chemotherapy · 2013
    Article
14. Pediatric sepsis: preparing for the future against a global scourge.Current infectious disease reports · 2012
    Article
15. Early initiation of low-dose corticosteroid therapy in the management of septic shock: a retrospective observational study.Critical care (London, England) · 2012
    Article
16. Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock.Critical care medicine · 2012
    Article
17. Intensive care medicine comes of age.Clinical medicine (London, England) · 2011
    Article
18. Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies.Expert opinion on drug metabolism & toxicology · 2011
    Review
19. Critical care trial design and interpretation: a primer.Critical care medicine · 2010
    Review
20. Systems engineering medicine: engineering the inflammation response to infectious and traumatic challenges.Journal of the Royal Society, Interface · 2010
    Review

Corrections and comments

• Comment on
  Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock.2008

Authors and funding

4 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as