Trial reportDiabetologia2008
Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.
Trial report in Diabetologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.BMJ (Clinical research ed.) · 2016Pooled it
- Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.PLoS genetics · 2013Pooled it
- Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.PLoS medicine · 2011Pooled it
- Trial
- Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry.Human molecular genetics · 2015Trial
- HbA1c as a predictor of diabetes and as an outcome in the diabetes prevention program: a randomized clinical trial.Diabetes care · 2015Trial
- FTO predicts weight regain in the Look AHEAD clinical trial.International journal of obesity (2005) · 2013Trial
- Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial.Human heredity · 2013Trial
- Obesity susceptibility loci and dietary intake in the Look AHEAD Trial.The American journal of clinical nutrition · 2012Trial
- Trial
- The genetics of obesity: aetiology, prevention and therapy.Nature metabolism · 2026Review
- An obesogenic FTO allele causes accelerated development, growth and insulin resistance in human skeletal muscle cells.Nature communications · 2025Article
- MicroRNAs Associated With Incident Diabetes in the Diabetes Prevention Program.The Journal of clinical endocrinology and metabolism · 2023Article
- Article
- Interplay of physical activity and genetic variants of the endothelial lipase on cardiovascular disease risk factors.Pediatric research · 2022Article
- Genetic test for the prescription of diets in support of physical activity.Acta bio-medica : Atenei Parmensis · 2020Article
- Common Variants in 22 Genes Regulate Response to Metformin Intervention in Children with Obesity: A Pharmacogenetic Study of a Randomized Controlled Trial.Journal of clinical medicine · 2019Article
- Gene-lifestyle interplay in type 2 diabetes.Current opinion in genetics & development · 2018Review
- Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?Diabetologia · 2017Review
- The importance of gene-environment interactions in human obesity.Clinical science (London, England : 1979) · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
aims/hypothesisThe single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity associated gene (FTO) and the rs7566605 SNP located 10 kb upstream of the insulin-induced gene 2 gene (INSIG2) have been proposed as risk factors for common obesity.
methodsWe tested for genotype-treatment interactions on changes in obesity-related traits in the Diabetes Prevention Program (DPP). The DPP is a randomised controlled trial of 3,548 high-risk individuals from 27 participating centres throughout the USA who were originally randomised to receive metformin, troglitazone, intensive lifestyle modification or placebo to prevent the development of type 2 diabetes. Measures of adiposity from computed tomography were available in a subsample (n = 908). This report focuses on the baseline and 1 year results.
resultsThe minor A allele at FTO rs9939609 was positively associated with baseline BMI (p = 0.003), but not with baseline adiposity or the change at 1 year in any anthropometric trait. For the INSIG2 rs7566605 genotype, the minor C allele was associated with more subcutaneous adiposity (second and third lumbar vertebrae [L2/3]) at baseline (p = 0.04). During follow-up, CC homozygotes lost more weight than G allele carriers (p = 0.009). In an additive model, we observed nominally significant gene-lifestyle interactions on weight change (p = 0.02) and subcutaneous (L2/3 [p = 0.01] and L4/5 [p = 0.03]) and visceral (L2/3 [p = 0.02]) adipose areas. No statistical evidence of association with physical activity energy expenditure or energy intake was observed for either genotype. CONCLUSIONS/
interpretationWithin the DPP study population, common variants in FTO and INSIG2 are nominally associated with quantitative measures of obesity, directly and possibly by interacting with metformin or lifestyle intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.