ArticleClinical and experimental nephrology2008
Analysis of intra-GBM microstructures in a SLE case with glomerulopathy associated with podocytic infolding.
Article in Clinical and experimental nephrology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 27 citations in OpenAlex.
- Morphological subtypes and clinicopathological features of podocyte infolding glomerulopathy: retrospective nationwide Japanese cohort study of 93 cases.Clinical and experimental nephrology · 2026Article
- Histopathological Examination of Clustering Microspheres and Podocyte Infolding in the Glomerular Basement Membrane Using Low-vacuum Scanning Electron Microscopy.Internal medicine (Tokyo, Japan) · 2026Article
- Podocyte infolding glomerulopathy in a Japanese girl with systemic lupus erythematosus.CEN case reports · 2026Article
- Podocyte Infolding Glomerulopathy: A Special Morphology of Podocyte Injury Caused by Heterogeneous Diseases.Kidney international reports · 2023Article
- IgA nephropathy with podocytic infolding glomerulopathy.Chronic diseases and translational medicine · 2023Article
- A case of Podocytic Infolding Glomerulopathy with SLE and literature review.BMC nephrology · 2021Review
- Podocytic infolding in Schimke immuno-osseous dysplasia with novel SMARCAL1 mutations: a case report.BMC nephrology · 2020Article
- Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys.Frontiers in immunology · 2020Review
- Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome.BMC nephrology · 2019Article
- A Case of Podocytic Infolding Glomerulopathy with Primary Sjögren's Syndrome and Hashimoto's Thyroiditis.Chinese medical journal · 2018Article
- A case of podocytic infolding glomerulopathy with multiple myeloma.BMC nephrology · 2014Article
- A large-sized bubbling appearance of the glomerular basement membrane in a patient with pulmonary limited AL amyloidosis and a past history of lupus nephritis.Clinical and experimental nephrology · 2011Article
- Membrane attack by complement: the assembly and biology of terminal complement complexes.Immunologic research · 2011Review
- Proposal of podocytic infolding glomerulopathy as a new disease entity: a review of 25 cases from nationwide research in Japan.Clinical and experimental nephrology · 2008Article
- Are the cytoplasmic microstructures within GBM pathologically significant?Clinical and experimental nephrology · 2008Article
- Characterization of Membranous Nephropathy with Microspherular Deposits.Glomerular diseasesArticle
- Podocyte Infolding Glomerulopathy Masquerading as Membranous Nephropathy - A Shared Pathogenesis?Indian journal of nephrologyArticle
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSystemically podocytic infolding into the GBM which causes nonargyrophilic holes in the GBM in association with intra-GBM microstructures has been considered as a new pathological entity. However, its pathomechanisms are largely unknown.
methodsWe analyzed intra-GBM microstructures in an SLE patient with glomerulopathy associated with podocytic infolding by immunoelectron microscopy for vimentin (a marker for both podocyte and endothelium) and C5b-9 and by 3D reconstruction of transmission electron microscopy (TEM) images by computer tomography method.
resultsImmunofluorescent study showed immunoglobulin deposition in a diffuse, capillary pattern; however, electron-dense deposits like stage 3 membranous nephropathy could be found only in some capillary loops by TEM in spite of the systemic existence of podocytic infolding and the intra-GBM microstructures. Three-dimensional reconstructed images of the TEM images revealed that some of the intra-GBM microstructures made connections with the podocyte. The clustered microstructures underneath the podocyte and their surroundings looked as a whole like the degraded part of podocyte in 3D reconstructed images. Immunoelectron microscopy showed that vimentin was positive in most intra-GBM microstructures. C5b-9 was positive along the entire epithelial side of the GBM and in some microstructures, suggesting that the podocytes may be attacked by C5b-9 and that the microstructures may contain C5b-9 bound cellular membranes.
conclusionIntra-GBM microstructures may be originated mainly from the podocyte. Podotyte and GBM injuries caused by C5b-9 attack to podocytes might contribute in part to podocytic infolding and intra-GBM microstructures in this case.
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