ArticleAntimicrobial agents and chemotherapy2008
Bacteriophage therapy and the mutant selection window.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Article
- Isolation and Characterization of Infection of Four New Bacteriophages Infecting aAntibiotics (Basel, Switzerland) · 2024Article
- Lytic activity of phages against bacterial pathogens infecting diabetic foot ulcers.Scientific reports · 2024Article
- Automating Predictive Phage Therapy Pharmacology.Antibiotics (Basel, Switzerland) · 2023Review
- Alternate Antimicrobial Therapies and Their Companion Tests.Diagnostics (Basel, Switzerland) · 2023Review
- Article
- Nisin Mutant Prevention Concentration and the Role of Subinhibitory Concentrations on Resistance Development by Diabetic FootAntibiotics (Basel, Switzerland) · 2022Article
- In Vivo Bacteriophages' Application for the Prevention and Therapy of Aquaculture Animals-Chosen Aspects.Animals : an open access journal from MDPI · 2022Review
- Phage Revolution Against Multidrug-Resistant Clinical Pathogens in Southeast Asia.Frontiers in microbiology · 2022Review
- Overcoming the growth-infectivity trade-off in a bacteriophage slows bacterial resistance evolution.Evolutionary applications · 2021Article
- Efficacy of Individual Bacteriophages Does Not Predict Efficacy of Bacteriophage Cocktails for Control ofFrontiers in microbiology · 2021Article
- Phage cocktail strategies for the suppression of a pathogen in a cross-feeding coculture.Microbial biotechnology · 2020Article
- Efficacy of phage cocktail AB-SA01 therapy in diabetic mouse wound infections caused by multidrug-resistant Staphylococcus aureus.BMC microbiology · 2020Article
- Article
- Therapeutic Effects of Intravitreously Administered Bacteriophage in a Mouse Model of Endophthalmitis Caused by Vancomycin-Sensitive or -Resistant Enterococcus faecalis.Antimicrobial agents and chemotherapy · 2019Article
- Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci.Infection and immunity · 2019Article
- Isolation and Characterization of a Bacteriophage Preying an Antifungal Bacterium.The plant pathology journal · 2016Article
- Exposure to phages has little impact on the evolution of bacterial antibiotic resistance on drug concentration gradients.Evolutionary applications · 2014Article
- Possible use of bacteriophages active against Bacillus anthracis and other B. cereus group members in the face of a bioterrorism threat.BioMed research international · 2014Review
- Phage therapy: eco-physiological pharmacology.Scientifica · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
We use kinetic models to investigate how to design antimicrobial phage therapies to minimize emergence of resistant bacteria. We do this by modifying the "mutant selection window" hypothesis in a way that accounts for the ongoing self-replication of the phage. We show that components of combination phage therapies need to be appropriately matched if treatment is to avoid the emergence of resistant bacteria. Matching of components is more easily achieved when phage dosages are high enough that ongoing phage replication is not needed for the clearance of the bacteria. Theoretical predictions such as ours need to be tested experimentally if applications of phage therapy are to avoid the problems of widespread resistance that have beset chemical antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.