ArticleThe Journal of cell biology2008
The keratin-binding protein Albatross regulates polarization of epithelial cells.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
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- Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause.Nature communications · 2020Article
- Establishing and regulating the composition of cilia for signal transduction.Nature reviews. Molecular cell biology · 2019Review
- Intermediate filaments and IF-associated proteins: from cell architecture to cell proliferation.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2019Review
- The complexity of the cilium: spatiotemporal diversity of an ancient organelle.Current opinion in cell biology · 2018Review
- Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components.Nature communications · 2018Article
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- Genomic and epigenomic analysis of high-risk prostate cancer reveals changes in hydroxymethylation and TET1.Oncotarget · 2016Article
- Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.The Journal of cell biology · 2016Article
- Exploring Mouse Protein Function via Multiple Approaches.PloS one · 2016Article
- HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.Cellular oncology (Dordrecht, Netherlands) · 2015Article
- Phosphorylation and Reorganization of Keratin Networks: Implications for Carcinogenesis and Epithelial Mesenchymal Transition.Biomolecules & therapeutics · 2015Review
- Identification of new susceptibility loci for IgA nephropathy in Han Chinese.Nature communications · 2015Article
- Uncovering adaptive evolution in the human lineage.BMC genomics · 2014Article
- The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK.The Journal of cell biology · 2013Article
- Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes.Nature communications · 2013Article
- Keratin 8 is required for the maintenance of architectural structure in thymus epithelium.PloS one · 2013Article
- Membrane traffic and synaptic cross-talk during host cell entry by Trypanosoma cruzi.Cellular microbiology · 2012Article
- Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells.The Journal of cell biology · 2012Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The keratin intermediate filament network is abundant in epithelial cells, but its function in the establishment and maintenance of cell polarity is unclear. Here, we show that Albatross complexes with Par3 to regulate formation of the apical junctional complex (AJC) and maintain lateral membrane identity. In nonpolarized epithelial cells, Albatross localizes with keratin filaments, whereas in polarized epithelial cells, Albatross is primarily localized in the vicinity of the AJC. Knockdown of Albatross in polarized cells causes a disappearance of key components of the AJC at cell-cell borders and keratin filament reorganization. Lateral proteins E-cadherin and desmoglein 2 were mislocalized even on the apical side. Although Albatross promotes localization of Par3 to the AJC, Par3 and ezrin are still retained at the apical surface in Albatross knockdown cells, which retain intact microvilli. Analysis of keratin-deficient epithelial cells revealed that keratins are required to stabilize the Albatross protein, thus promoting the formation of AJC. We propose that keratins and the keratin-binding protein Albatross are important for epithelial cell polarization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.