Evidence map›Paper›PMID 18838550›Full record

ArticleThe Journal of cell biology2008

Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters.

Beatrice Maria Filippi, Dario R Alessi

Abstract readComment
In one paragraph

Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Beatrice Maria FilippiMedical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK. b.filippi@dundee.ac.uk
Dario R Alessi

Funding

Medical Research Council MC_U127070193
6 · The paper itself

Abstract

A question preoccupying many researchers is how signal transduction pathways control metabolic processes and energy production. A study by Jang et al. (Jang, C., G. Lee, and J. Chung. 2008. J. Cell Biol. 183:11-17) provides evidence that in Drosophila melanogaster a signaling network controlled by the LKB1 tumor suppressor regulates trafficking of an Sln/dMCT1 monocarboxylate transporter to the plasma membrane. This enables cells to import additional energy sources such as lactate and butyrate, enhancing the repertoire of fuels they can use to power vital activities.

Indexed as

AMP-Activated Protein Kinase KinasesAnimalsApoptosisButyratesCell PolarityDrosophila melanogasterDrosophila ProteinsHumansLactic AcidModels, BiologicalMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersProtein KinasesProtein TransportSignal TransductionSymportersAMP-Activated Protein Kinase KinasesButyratesDrosophila ProteinsLactic AcidLKB1 protein, DrosophilaMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersProtein KinasesSymporters

Identifiers

PMID18838550
PMCPMC2557034

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.