ArticleInfection and immunity2008
Primary activation of antigen-specific naive CD4+ and CD8+ T cells following intranasal vaccination with recombinant bacteria.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Bacterial derivatives mediated drug delivery in cancer therapy: a new generation strategy.Journal of nanobiotechnology · 2024Review
- Topical Administration ofCells · 2023Article
- Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TScience advances · 2020Article
- Pulmonary mucosal immunity mediated through CpG provides adequate protection against pulmonary Mycobacterium tuberculosis infection in the mouse model. A role for type I interferon.Tuberculosis (Edinburgh, Scotland) · 2020Article
- Contact-dependent delivery of IL-2 by dendritic cells to CD4 T cells in the contraction phase promotes their long-term survival.Protein & cell · 2020Article
- Recent trends and advances in microbe-based drug delivery systems.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Review
- Heterologous Prime-Boost Combinations Highlight the Crucial Role of Adjuvant in Priming the Immune System.Frontiers in immunology · 2018Article
- Transcriptomics of the Vaccine Immune Response: Priming With Adjuvant Modulates Recall Innate Responses After Boosting.Frontiers in immunology · 2018Article
- Non-invasive administration of biodegradable nano-carrier vaccines.American journal of translational research · 2017Review
- Immunity in the spleen and blood of mice immunized with irradiated Toxoplasma gondii tachyzoites.Medical microbiology and immunology · 2016Article
- Modulation of Primary Immune Response by Different Vaccine Adjuvants.Frontiers in immunology · 2016Article
- Vaginal type-II mucosa is an inductive site for primary CD8⁺ T-cell mucosal immunity.Nature communications · 2015Article
- Characterization of the Antigen-Specific CD4(+) T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes.Frontiers in immunology · 2015Article
- A Stochastic Model for CD4+ T Cell Proliferation and Dissemination Network in Primary Immune Response.PloS one · 2015Article
- The role of host and microbial factors in the pathogenesis of pneumococcal bacteraemia arising from a single bacterial cell bottleneck.PLoS pathogens · 2014Article
- CD4(+) T Cell Priming as Biomarker to Study Immune Response to Preventive Vaccines.Frontiers in immunology · 2013Review
- Article
- Prime-boost strategies in mucosal immunization affect local IgA production and the type of th response.Frontiers in immunology · 2013Article
- Distribution of primed T cells and antigen-loaded antigen presenting cells following intranasal immunization in mice.PloS one · 2011Article
- Cellular immune responses to nine Mycobacterium tuberculosis vaccine candidates following intranasal vaccination.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary activation of T-helper and T-cytotoxic cells following mucosal immunization with recombinant Streptococcus gordonii was studied in vivo by adoptive transfer of ovalbumin (OVA)-specific transgenic CD8(+) (OT-I) and CD4(+) (OT-II) T cells. A recombinant strain, expressing on the surface the vaccine antigen Ag85B-ESAT-6 from Mycobacterium tuberculosis fused to OVA T-helper and T-cytotoxic epitopes (peptides 323 to 339 and 257 to 264), was constructed and used to immunize C57BL/6 mice by the intranasal route. Recombinant, but not wild-type, bacteria induced OVA-specific CD4(+) and CD8(+) T-cell clonal expansion in cervical lymph nodes, lung, and spleen. OVA-specific CD4(+) and CD8(+) T-cell proliferation appeared first in cervical lymph nodes and later in the spleen, suggesting a possible migration of activated cells from the inductive site to the systemic district. A significant correlation between the percentages of CD4(+) and CD8(+) proliferating T cells was observed for each animal. The expression of CD69, CD44, and CD45RB on proliferating T lymphocytes changed as a function of the cell division number, confirming T-cell activation following the antigen encounter. These data indicate that intranasal immunization with recombinant S. gordonii is capable of inducing primary activation of naive antigen-specific CD4(+) and CD8(+) T cells, both locally and systemically.
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