ArticleVirology journal2008
Inhibition of G1P3 expression found in the differential display study on respiratory syncytial virus infection.
Article in Virology journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- The Impact of RSV-Associated Respiratory Disease on Children in Asia.Journal of pediatric infectious diseases · 2019Review
- Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.The Journal of biological chemistry · 2017Article
- SAMHD1's protein expression profile in humans.Journal of leukocyte biology · 2015Article
- SAMHD1 Gene Mutations Are Associated with Cerebral Large-Artery Atherosclerosis.BioMed research international · 2015Article
- Article
- Polymorphisms of the SAMHD1 gene are not associated with the infection and natural control of HIV type 1 in Europeans and African-Americans.AIDS research and human retroviruses · 2012Article
- From expression pattern to genetic association in asthma and asthma-related phenotypes.BMC research notes · 2012Article
- Monogenic forms of systemic lupus erythematosus: new insights into SLE pathogenesis.Pediatric rheumatology online journal · 2012Article
- SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein.Frontiers in microbiology · 2012Article
- Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase.The Journal of biological chemistry · 2011Article
- SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx.Nature · 2011Article
- Homozygous mutation in SAMHD1 gene causes cerebral vasculopathy and early onset stroke.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The Fourth Major Restriction Factor Against HIV/SIV.Frontiers in microbiology · 2011Article
- Emerging roles of FAM14 family members (G1P3/ISG 6-16 and ISG12/IFI27) in innate immunity and cancer.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2011Review
- Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression.Human mutation · 2010Article
- Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene.Journal of virology · 2010Article
- Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity.Human molecular genetics · 2009Review
- Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response.Nature genetics · 2009Article
- The host response and molecular pathogenesis associated with respiratory syncytial virus infection.Future microbiology · 2009Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRespiratory syncytial virus (RSV) is the leading viral pathogen associated with bronchiolitis and lower respiratory tract disease in infants and young children worldwide. The respiratory epithelium is the primary initiator of pulmonary inflammation in RSV infections, which cause significant perturbations of global gene expression controlling multiple cellular processes. In this study, differential display reverse transcription polymerase chain reaction amplification was performed to examine mRNA expression in a human alveolar cell line (SPC-A1) infected with RSV.
resultsOf the 2,500 interpretable bands on denaturing polyacrylamide gels, 40 (1.6%) cDNA bands were differentially regulated by RSV, in which 28 (70%) appeared to be upregulated and another 12 (30%) appeared to be downregulated. Forty of the expressed sequence tags (EST) were isolated, and 20 matched homologs in GenBank. RSV infection upregulated the mRNA expression of chemokines CC and CXC and interfered with type alpha/beta interferon-inducible gene expression by upregulation of MG11 and downregulation of G1P3.
conclusionRSV replication could induce widespread changes in gene expression including both positive and negative regulation and play a different role in the down-regulation of IFN-alpha and up-regulation of IFN-gamma inducible gene expression, which suggests that RSV interferes with the innate antiviral response of epithelial cells by multiple mechanisms.
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