Evidence map›Paper›PMID 18837637›Full record

ReviewExperimental and clinical psychopharmacology2008

Opioids and the treatment of chronic pain: controversies, current status, and future directions.

Andrew Rosenblum, Lisa A Marsch, Herman Joseph, Russell K Portenoy

2 registry-linked trialsOpen access · greenAbstract readHistorical ArticleReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental and clinical psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 239 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
239citing papers in PubMed, 11 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05896878 naterminatednot on this mapstarted 2023, after this paper: background citation

The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients

TypeinterventionalSponsorHudson MedicalRan2023 to 2024Enrolled1ConditionsPain, Chronic, Opioid Dependence, Opioid Use, Inflammation ChronicArmsRoot.Health Dietary Supplement
NCT06689124 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

A Randomized Study Comparing of Three Doses Nebulized Fentanyl in Older Adults With Severe Musculoskeletal Pain at the Emergency Department

TypeinterventionalSponsorBangkok Metropolitan Administration Medical College and Vajira HospitalRan2024 to 2025Enrolled120ConditionsTreatment Side Effects, Musculoskeletal PainArmsNebulized fentanyl
3 · Its place in the literature

Who cites it

239 citing papers in PubMed, 11 syntheses or guidelines pooled it, 645 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Health-related quality of life in patients receiving long-term opioid therapy: a systematic review with meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017
    Pooled it
  10. Opioids for chronic non-cancer pain in children and adolescents.The Cochrane database of systematic reviews · 2017
    Pooled it
  11. Opioids for cancer-related pain in children and adolescents.The Cochrane database of systematic reviews · 2017
    Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Article
  18. Article
  19. Article
  20. Review

179 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Andrew RosenblumNational Development and Research Institutes, New York, NY 10010, USA. rosenblum@ndri.org
Lisa A Marsch
Herman Joseph
Russell K Portenoy
National Development and Research Institutes · USMount Sinai Beth Israel · US

Funding

Sublingual Buprenorphine for Chronic Pain in Patients at Risk for Drug AbuseR21DA022675 · NIDA · NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC. · PI ROSENBLUM, ANDREW BRUCE · 2006 to 2007
$443k
NIDA NIH HHS R21 DA022675
6 · The paper itself

Abstract

Opioids have been regarded for millennia as among the most effective drugs for the treatment of pain. Their use in the management of acute severe pain and chronic pain related to advanced medical illness is considered the standard of care in most of the world. In contrast, the long-term administration of an opioid for the treatment of chronic noncancer pain continues to be controversial. Concerns related to effectiveness, safety, and abuse liability have evolved over decades, sometimes driving a more restrictive perspective and sometimes leading to a greater willingness to endorse this treatment. The past several decades in the United States have been characterized by attitudes that have shifted repeatedly in response to clinical and epidemiological observations, and events in the legal and regulatory communities. The interface between the legitimate medical use of opioids to provide analgesia and the phenomena associated with abuse and addiction continues to challenge the clinical community, leading to uncertainty about the appropriate role of these drugs in the treatment of pain. This narrative review briefly describes the neurobiology of opioids and then focuses on the complex issues at this interface between analgesia and abuse, including terminology, clinical challenges, and the potential for new agents, such as buprenorphine, to influence practice.

Indexed as

Analgesics, OpioidAnimalsBuprenorphineChronic DiseaseDrug ToleranceHistory, AncientHumansNarcotic AntagonistsNervous SystemOpioid-Related DisordersPainSubstance Withdrawal SyndromeAnalgesics, OpioidBuprenorphineNarcotic Antagonists

Identifiers

PMID18837637
PMCPMC2711509
OpenAlexW1993178542

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.