ReviewExperimental and clinical psychopharmacology2008
Evaluation of prescription opioids using operant-based pain measures in rats.
Review in Experimental and clinical psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Operant conditioning through positive reinforcement in the ghost crab (Ocypode quadrata).Learning & behavior · 2026Article
- Naloxone's dose-dependent displacement of [Scientific reports · 2022Article
- Neuroethics and Animals: Report and Recommendations From the University of Pennsylvania Animal Research Neuroethics Workshop.ILAR journal · 2021Article
- Effects of oxycodone and diazepam alone and in combination on operant nociception.Behavioural pharmacology · 2020Article
- Effect of Low Intensity Magnetic Field Stimulation on Calcium-Mediated Cytotoxicity After Mild Spinal Cord Contusion Injury in Rats.Annals of neurosciences · 2020Article
- Use of Flavored Tablets of Gabapentin and Carprofen to Attenuate Postoperative Hypersensitivity in an Incisional Pain Model in Rats (Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Evaluation of a Postoperative Pain-Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive-Ratio Food-Maintained Responding.Drug development research · 2015Article
- Changes in saccharin preference behavior as a primary outcome to evaluate pain and analgesia in acetic acid-induced visceral pain in mice.Journal of pain research · 2015Article
- Operant nociception in nonhuman primates.Pain · 2014Article
- Thermal sensitivity across ages and during chronic fentanyl administration in rats.Psychopharmacology · 2014Article
- "Bedside-to-Bench" Behavioral Outcomes in Animal Models of Pain: Beyond the Evaluation of Reflexes.Current neuropharmacology · 2013Article
- Use of the Operant Orofacial Pain Assessment Device (OPAD) to measure changes in nociceptive behavior.Journal of visualized experiments : JoVE · 2013Article
- Current challenges in translational pain research.Trends in pharmacological sciences · 2012Article
- Article
- Negative reinforcement reveals non-evoked ongoing pain in mice with tissue or nerve injury.The journal of pain · 2012Article
- Effects of morphine on thermal sensitivity in adult and aged rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Effects of chronic fentanyl administration on physical performance of aged rats.Experimental gerontology · 2011Article
- Rationale and methods for assessment of pain-depressed behavior in preclinical assays of pain and analgesia.Methods in molecular biology (Clifton, N.J.) · 2010Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Opioids are the most effective compounds available for the relief of pain, yet there are a number of side effects that are of great concern to clinicians. For example, opioids are powerful reinforcers, and the treatment of pain using opioids could lead to the development of addiction. In addition, there is an increasing body of literature demonstrating that the repeated administration of opioids could lead to a phenomenon called opioid-induced hyperalgesia (i.e., increased sensitivity to painful stimulation). Studies examining these potential adverse effects are necessary in the development of novel analgesics. Furthermore, most studies of pain sensitivity and pain relief use reflex-based procedures to identify analgesics; however, it is argued here that operant-based procedures provide measures that are more analogous to the human condition (i.e., the mechanisms of pain are similar to those in humans) and should be useful in the assessment of novel analgesics. A series of studies examining the effects of opioids and the influence of variables such as age are discussed to demonstrate the utility of this approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.