ArticleLangmuir : the ACS journal of surfaces and colloids2008
Enhanced fluorescence images for labeled cells on silver island films.
Article in Langmuir : the ACS journal of surfaces and colloids, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 50 citations in OpenAlex.
- Development of A Fission Yeast Cell-Based Platform for High Throughput Screening of HIV-1 Protease Inhibitors.Current HIV research · 2019Article
- Recent advances in synthetic methods and applications of silver nanostructures.Nanoscale research letters · 2018Review
- Effect of the Composition of Lanthanide Complexes on Their Luminescence Enhancement by Ag@SiO₂ Core-Shell Nanoparticles.Nanomaterials (Basel, Switzerland) · 2018Article
- Recent Advances in Biosensing With Photonic Crystal Surfaces: A Review.IEEE sensors journal · 2016Article
- Light-Enhanced Fluorescence of Multi-Level Cavitands Possessing Pyridazine Upper rim.Journal of fluorescence · 2016Article
- Article
- Metal plasmon-coupled fluorescence imaging and label free coenzyme detection in cells.Biochemical and biophysical research communications · 2012Article
- Photonic crystal enhanced fluorescence for early breast cancer biomarker detection.Journal of biophotonics · 2012Review
- Controlling the synthesis and assembly of silver nanostructures for plasmonic applications.Chemical reviews · 2011Review
- Metallic-Nanostructure-Enhanced Fluorescence of Single Flavin Cofactor and Single Flavoenzyme Molecules.The journal of physical chemistry. C, Nanomaterials and interfaces · 2011Article
- A cellular screening assay using analysis of metal-modified fluorescence lifetime.Biophysical journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Silver island films (SIFs) were deposited on glass substrates to serve as supports. T-Lymphocytic (PM1) cell lines were labeled by Alexa Fluor 680-dextran conjugates on the membranes or by YOYO in the nuclei. The fluorescence images of the cell lines were recorded in the emission intensity and lifetime using scanning confocal microscopy. The fluorescence signals by the fluorophores bound on the cell membranes were enhanced significantly by SIF supports as compared with those on the glass. In addition to the increase in the intensity, there was a dramatic shortening of the emission lifetime. In contrast to the Alexa Fluor 680 fluorophores on the membranes, the YOYO fluorophores intercalated in the cell nuclei were not influenced significantly by the silver islands. This result can be interpreted by an effect of the distance on coupling between the fluorophores and metal particles: the fluorophores on the cell membranes are localized within, but the fluorophores in the cell nuclei are beyond the region of metal-enhanced fluorescence. Thus, the metal supports can be used to improve the detection sensitivity for target molecules on cell surfaces when they are fluorescently labeled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.