ArticleWorld journal of gastroenterology2008
Characterization of hepatic progenitors from human fetal liver during second trimester.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Immunogenicity of Fetal Liver-Derived Progenitor and Stem Cells: Expression of MHC Molecules.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Long-term and non-invasiveWorld journal of hepatology · 2022Article
- Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors.EMBO reports · 2022Article
- Organoid transplant approaches for the liver.Transplant international : official journal of the European Society for Organ Transplantation · 2021Review
- Review
- Hyaluronan-Based Grafting Strategies for Liver Stem Cell Therapy and Tracking Methods.Stem cells international · 2019Review
- Bioengineered humanized livers as better three-dimensional drug testing model system.World journal of hepatology · 2018Article
- Hepatic progenitor cell activation in liver repair.Liver research (Beijing, China) · 2017Article
- Hepatic stem cells: A viable approach for the treatment of liver cirrhosis.World journal of stem cells · 2015Review
- Prognostic impact of tumour-infiltrating immune cells on biliary tract cancer.British journal of cancer · 2013Article
- Human Liver Progenitor Cells for Liver Repair.Cell medicine · 2013Review
- Thinking outside the liver: induced pluripotent stem cells for hepatic applications.World journal of gastroenterology · 2013Review
- Fetal liver cell transplantation as a potential alternative to whole liver transplantation?Journal of gastroenterology · 2011Review
- Convenient and efficient enrichment of the CD133+ liver cells from rat fetal liver cells as a source of liver stem/progenitor cells.Stem cell reviews and reports · 2011Article
- Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines.Cancer science · 2010Article
- Culture of newborn monkey liver epithelial progenitor cells in chemical defined serum-free medium.In vitro cellular & developmental biology. Animal · 2010Article
- Progress in stem cell-derived technologies for hepatocellular carcinoma.Stem cells and cloning : advances and applications · 2010Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo enrich hepatic progenitors using epithelial cell adhesion molecule (EpCAM) as a marker from human fetal liver and investigate the expression of human leukocyte antigen (HLA) and their markers associated with hepatic progenitor cells.
methodsEpCAM +ve cells were isolated using magnetic cell sorting (MACS) from human fetuses (n = 10) at 15-25 wk gestation. Expression of markers for hepatic progenitors such as albumin, alpha-fetoprotein (AFP), CD29 (integrin beta1), CD49f (integrin alpha6) and CD90 (Thy 1) was studied by using flow cytometry, immunocytochemistry and RT-PCR; HLA class I (A, B, C) and class II (DR) expression was studied by flow cytometry only.
resultsFACS analysis indicated that EpCAM +ve cells were positive for CD29, CD49f, CD90, CD34, HLA class I, albumin and AFP but negative for HLA class II (DR) and CD45. RT PCR showed that EpCAM +ve cells expressed liver epithelial markers (CK18), biliary specific marker (CK19) and hepatic markers (albumin, AFP). On immunocytochemical staining, EpCAM +ve cells were shown positive signals for CK18 and albumin.
conclusionOur study suggests that these EpCAM +ve cells can be used as hepatic progenitors for cell transplantation with a minimum risk of alloreactivity and these cells may serve as a potential source for enrichment of hepatic progenitor.
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