ArticleWorld journal of gastroenterology2008
Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy: potential role of insulin.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Systematic Review with Network Meta-Analysis: Antidiabetic Medication and Risk of Hepatocellular Carcinoma.Scientific reports · 2016Pooled it
- Systematic review and meta-analysis of insulin therapy and risk of cancer.Hormones & cancer · 2012Pooled it
- Case Report: Extreme resistance to subcutaneous insulin in a cirrhotic patient with new-onset diabetes that resolved after transplantation.Frontiers in endocrinology · 2025Article
- Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation.Biomedicines · 2022Article
- Integrated computational approaches to screen gene expression data to determine key genes and therapeutic targets for type-2 diabetes mellitus.Saudi journal of biological sciences · 2022Article
- Identifying key genes and screening therapeutic agents associated with diabetes mellitus and HCV-related hepatocellular carcinoma by bioinformatics analysis.Saudi journal of biological sciences · 2021Article
- Metformin Improves Biochemical and Pathophysiological Changes in Hepatocellular Carcinoma with Pre-Existed Diabetes Mellitus Rats.Pathogens (Basel, Switzerland) · 2021Article
- Coffee consumption and risk of hepatocellular carcinoma: a meta-analysis of eleven epidemiological studies.OncoTargets and therapy · 2016Article
- Cancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai.BMC cancer · 2015Article
- Prevention of hepatocellular carcinoma by correction of metabolic abnormalities: Role of statins and metformin.World journal of hepatology · 2015Review
- Diabetes Mellitus Predicts Occurrence of Cirrhosis and Hepatocellular Cancer in Alcoholic Liver and Non-alcoholic Fatty Liver Diseases.Journal of clinical and translational hepatology · 2015Article
- Type 1 and type 2 diabetes and cancer mortality in the 2002-2009 cohort of 39,811 French dialyzed patients.PloS one · 2015Article
- Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention.International journal of medical sciences · 2014Review
- Insulin resistance in euglycemic cirrhosis.Annals of gastroenterology · 2014Article
- Impact of type 2 diabetes mellitus on the prognosis of early stage triple-negative breast cancer in People's Republic of China.OncoTargets and therapy · 2014Article
- NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma.Cancer cell · 2013Article
- Diabetes mellitus impacts risk of macrovascular invasion in patients undergoing transplantation for hepatocellular carcinoma.BMC gastroenterology · 2013Article
- Article
- Increased risk of cancer in patients with type 2 diabetes mellitus: a retrospective cohort study in China.BMC public health · 2012Article
- The maternal womb: a novel target for cancer prevention in the era of the obesity pandemic?European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the relationships between Type 2 diabetes mellitus (DM2) and the risk of hepatocellular carcinoma (HCC).
methodsWe studied the association between DM2 and HCC in a large case-control study that enrolled 465 consecutive Caucasian patients with HCC (78.3% males, mean age 68.5 +/- 8.9 years) compared with an age and sex matched control group of 490 subjects.
resultsPrevalence of DM2 was significantly higher in HCC patients (31.2% vs 12.7%; OR = 3.12, 95% CI: 2.22-4.43) and in HCC cases with alcohol abuse. DM2 has been diagnosed before the appearance of HCC in 84.1% of diabetic HCC subjects with mean duration of 141.5 mo, higher in cases treated with insulin than in those with oral antidiabetic agents (171.5 vs 118.7 mo). Compared to controls, males DM2 with HCC were more frequently treated with insulin (38.1% vs 17.6%, P = 0.009) and with sulfonylurea with or without metformin than with diet with or without metformin (84% vs 68.3%, P = 0.049).
conclusionDM2 in our patients is associated with a 3-fold increase risk of HCC. In most of our cases DM2 pre-existed to HCC. Patients with DM2 and chronic liver disease, particularly insulin treated males, should be considered for HCC close surveillance programs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.