ArticleGlia2009
Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: implications for glioma histogenesis and biology.
Article in Glia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Targeting Pediatric Glioblastomas by Combining OLIG2 Inhibitor CT-179 with Fractionated Radiation in a Panel of Patient-Derived Orthotopic Xenograft Mouse Models.International journal of molecular sciences · 2026Article
- Novel TCF4:TCF12 heterodimer inhibits glioblastoma growth.Molecular oncology · 2024Article
- Dysregulation of inflammasome activation in glioma.Cell communication and signaling : CCS · 2023Review
- Companion animal models of neurological disease.Journal of neuroscience methods · 2020Review
- To Become or Not to Become Tumorigenic: Subventricular ZoneFrontiers in oncology · 2020Review
- Cell type-specific epigenetic links to schizophrenia risk in the brain.Genome biology · 2019Article
- Single-cell transcriptome analysis of lineage diversity in high-grade glioma.Genome medicine · 2018Article
- Twist1 mediated regulation of glioma tumorigenicity is dependent on mode of mouse neural progenitor transformation.Oncotarget · 2017Article
- Glia: silent partners in energy homeostasis and obesity pathogenesis.Diabetologia · 2017Review
- Homeobox genes gain trimethylation of histone H3 lysine 4 in glioblastoma tissue.Bioscience reports · 2016Article
- Caudatin Inhibits Human Glioma Cells Growth Through Triggering DNA Damage-Mediated Cell Cycle Arrest.Cellular and molecular neurobiology · 2015Article
- Review
- Microglial proliferation in the brain of chronic alcoholics with hepatic encephalopathy.Metabolic brain disease · 2014Article
- Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells.Glia · 2014Article
- Pre-B-cell leukemia homeobox interacting protein 1 is overexpressed in astrocytoma and promotes tumor cell growth and migration.Neuro-oncology · 2014Article
- The Olig family affects central nervous system development and disease.Neural regeneration research · 2014Review
- SOX2+ cell population from normal human brain white matter is able to generate mature oligodendrocytes.PloS one · 2014Article
- LGR5 is a proneural factor and is regulated by OLIG2 in glioma stem-like cells.Cellular and molecular neurobiology · 2013Article
- Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma.Cancer research · 2012Article
- The cellular origin for malignant glioma and prospects for clinical advancements.Expert review of molecular diagnostics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The capacity of adult human glial progenitor cells (AGPs), to proliferate and undergo multipotent differentiation, positions them as ideal candidate cells of origin for human gliomas. To investigate this potential role we identified AGPs as mitotically active Olig2 cells in nonneoplastic adult human brain and gliomas. We conservatively estimated that one in 5,000 human temporal lobe neocortical gray or subcortical white matter cells is mitotic. Extrapolating from a mean Olig2/Mib-1 labeling index (LI) of 52% and total cell number of 100 billion, we estimated the overall prevalence of mitotic Olig2 AGPs in nonneoplastic human brain parenchyma at 10 million. These data identify a large reservoir of Olig2 AGPs which could be potential targets for human gliomagenesis. The vast majority of mitotic cells in Grade II and Grade III gliomas of all histologic subtypes expressed Olig2 (mean LI 75%) but rarely S100B (LI 0.6%), identifying the Olig2 cell as a distinct contributor to the proliferating cell population of human gliomas of both oligodendroglial and astrocytic lineages. In the most malignant Grade IV glioma, or glioblastoma multiforme (GBM), the prevalence of Olig2/Mib-1 cells was significantly decreased (24.5%). The significantly lower Olig2/Mib-1 LI in GBMs suggests that a decrease in the prevalence of Olig2 cells to the total mitotic cell pool accompanies increasing malignancy. The novel framework provided by this quantitative and comparative analysis supports future studies to examine the histogenetic role of Olig2 AGPs in adult gliomas, their potential contribution to the tumor stroma and the molecular role of Olig2 in glioma pathogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.