ArticleWorld journal of surgery2008
Clinical significance of p53 protein expression in papillary thyroid carcinoma.
Article in World journal of surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Rationale for Testing TP53 Mutations in Thyroid Cancer-Original Data and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Pathological characteristics of cervical lymph node metastases in papillary thyroid carcinoma compared with lung adenocarcinoma.Frontiers in oncology · 2026Article
- Molecular Diagnostics and Personalized Therapeutics in Differentiated Thyroid Carcinoma: A Clinically Oriented Review.Diagnostics (Basel, Switzerland) · 2025Review
- InvestigatingInternational journal of molecular sciences · 2024Article
- The Relationship between Oxidative Status and Radioiodine Treatment Qualification among Papillary Thyroid Cancer Patients.Cancers · 2023Article
- Unfolding of Imminent Bio-Signatures in the Prognosis of Thyroid Cancer; The Emergence of Estrogen Related Receptor Gamma (ERRγ) as a Hurricane.Asian Pacific journal of cancer prevention : APJCP · 2023Review
- YAP1 and P53 Expression in Papillary Thyroid Carcinoma.Iranian journal of pathology · 2023Article
- Original tumour suppressor gene polycystic kidney and hepatic disease 1-like 1 is associated with thyroid cancer cell progression.Oncology letters · 2019Article
- Evaluation of MEDAG gene expression in papillary thyroid microcarcinoma: associations with histological features, regional lymph node metastasis and prognosis.Scientific reports · 2019Article
- Upregulated LAMB3 increases proliferation and metastasis in thyroid cancer.OncoTargets and therapy · 2018Article
- MRI Texture Analysis Reflects Histopathology Parameters in Thyroid Cancer - A First Preliminary Study.Translational oncology · 2017Article
- A Concise Atlas of Thyroid Cancer Next-Generation Sequencing Panel ThyroSeq v.2.Molecular imaging and radionuclide therapy · 2017Article
- Correlation of BRAF mutation and SUVEndocrine · 2017Article
- Tall cell variant of papillary thyroid carcinoma: current evidence on clinicopathologic features and molecular biology.Oncotarget · 2016Review
- Decreased expression of p27 is associated with malignant transformation and extrathyroidal extension in papillary thyroid carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Associations of the BRAF (V600E) mutation and p53 protein expression with clinicopathological features of papillary thyroid carcinomas patients.Oncology letters · 2015Article
- Pri-Mir-34b/C and Tp-53 Polymorphisms are Associated With The Susceptibility of Papillary Thyroid Carcinoma: A Case-Control Study.Medicine · 2015Observational
- Differential expression patterns and clinical significance of estrogen receptor-α and β in papillary thyroid carcinoma.BMC cancer · 2014Article
- P53 and expression of immunological markers may identify early stage thyroid tumors.Clinical & developmental immunology · 2013Article
- Prognostic value of oncoprotein expressions in thyroid papillary carcinoma.Medical oncology (Northwood, London, England) · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough mutations in the p53 suppressor gene in thyroid carcinoma have usually been detected in anaplastic carcinoma, P53 protein expression has been detected immunohistochemically in papillary thyroid carcinoma (PTC). In the present study, we examined the immunohistochemical expression of P53 protein in PTC to investigate the relations between its expression and the clinicopathologic features.
methodsThe study was performed on 68 patients in whom thyroidectomy with lymph node dissection had been performed to treat PTC at Teikyo University Hospital. Expression of P53 protein was evaluated immunohistochemically in sections of paraffin-embedded tissue in 68 primary tumors and 196 lymph node metastases.
resultsOverexpression of P53 protein in the primary tumor was observed in 29 cases (43%). Statistical analysis revealed significant correlation between P53 protein expression in the primary tumor and large tumor size (unpaired t-test: p < 0.01), the presence of lymph node metastasis (unpaired t-test: p < 0.05), and the mean number of lymph node metastases (unpaired t-test: p < 0.05). Although 29 (43%) of the primary tumors overexpressed P53 protein, 143 (73%) of the metastatic lymph nodes overexpressed P53 protein irrespective of whether there was P53 overexpression by the primary tumor.
conclusionsThe results of this study suggest that immunohistochemistry for P53 in the primary tumor could be useful in the clinical evaluation of patients with PTC. Moreover, P53 protein overexpression in lymph node metastasis may be useful as a treatment guide or target for lymph node recurrences.
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