ArticleInternational urology and nephrology2009
Procalcitonin for the early prediction of renal parenchymal involvement in children with UTI: preliminary results.
Article in International urology and nephrology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
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14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children.The Cochrane database of systematic reviews · 2020Pooled it
- Diagnostic value of serum procalcitonin for acute pyelonephritis in infants and children with urinary tract infections: an updated meta-analysis.World journal of urology · 2016Pooled it
- Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children.The Cochrane database of systematic reviews · 2015Pooled it
- Meta-analysis and systematic review of procalcitonin-guided therapy in respiratory tract infections.Antimicrobial agents and chemotherapy · 2011Pooled it
- Review
- Serum Interleukin-6 and Interleukin-8 are Sensitive Markers for Early Detection of Pyelonephritis and Its Prevention to Progression to Chronic Kidney Disease.International journal of preventive medicine · 2021Article
- Levels of serum procalcitonin and C-reactive protein for evaluating pulmonary bacterial infection in patients with lupus erythematosus.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Article
- Article
- Current medical diagnosis and management of vesicoureteral reflux in children.Nephro-urology monthly · 2014Review
- Article
- Procalcitonin: a key marker in children with urinary tract infection.Advances in urology · 2011Article
- Predictors of abnormal renal cortical scintigraphy in children with first urinary tract infection: the importance of time factor.International urology and nephrology · 2010Article
- Novel biomarkers for the diagnosis of urinary tract infection-a systematic review.Biomarker insights · 2009Article
- The rapidly expanding role of procalcitonin as a diagnostic and prognostic assay besides in UTIs.International urology and nephrology · 2009Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to establish the most reliable marker for distinguishing urinary tract infections (UTI) with and without renal parenchymal involvement (RPI), we recorded the clinical features and admission leukocyte count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum procalcitonin (PCT) in 57 children (including 43 girls) aged 2-108 months admitted with a first episode of UTI. RPI was evaluated by Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy within 7 days of admission. To establish cut-off points for ESR, CRP, and PCT, we used receiver operating characteristics curves and compared the area under the curve for ESR, CRP, and PCT. Twenty-seven children were diagnosed as having RPI based on positive renal scintigraphy. A body temperature of >38 degrees C, a history of diarrhea, and poor oral intake were more common in patients with RPI. ESR, CRP, and PCT, but not leukocyte count, were significantly higher in patients with RPI (P < 0.001). PCT was more sensitive and specific for the diagnosis of upper versus lower UTI than ESR and CRP. Using a cut-off value of 0.85 ng/ml, PCT had the best performance, with sensitivity, specificity, and positive and negative predictive values of 89%, 97%, 96%, and 91% respectively. Serum PCT is a better marker than ESR, CRP, and leukocyte count for the early prediction of RPI in children with a first episode of UTI.
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