ArticleHistochemistry and cell biology2009
An age-dependent proliferation is involved in the postnatal development of interstitial cells of Cajal in the small intestine of mice.
Article in Histochemistry and cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The Potential for Gut Organoid Derived Interstitial Cells of Cajal in Replacement Therapy.International journal of molecular sciences · 2017Review
- Stem Cell Factor/Kit Signal Insufficiency Contributes to Hypoxia-Induced Intestinal Motility Dysfunctions in Neonatal Mice.Digestive diseases and sciences · 2017Article
- Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells.The Journal of comparative neurology · 2016Article
- Spatial Noise in Coupling Strength and Natural Frequency within a Pacemaker Network; Consequences for Development of Intestinal Motor Patterns According to a Weakly Coupled Phase Oscillator Model.Frontiers in neuroscience · 2016Article
- Walker 256 tumor-bearing rats demonstrate altered interstitial cells of Cajal. Effects on ICC in the Walker 256 tumor model.Neurogastroenterology and motility · 2016Article
- Developmental changes in postnatal murine intestinal interstitial cell of Cajal network structure and function.Annals of biomedical engineering · 2014Article
- Interstitial cells: regulators of smooth muscle function.Physiological reviews · 2014Review
- Numerical metrics for automated quantification of interstitial cell of Cajal network structural properties.Journal of the Royal Society, Interface · 2013Article
- Establishment of pacemaker activity in tissues allotransplanted with interstitial cells of Cajal.Neurogastroenterology and motility · 2013Article
- The distribution of HCN2-positive cells in the gastrointestinal tract of mice.Journal of anatomy · 2012Article
- Changes in interstitial cells of cajal with age in the human stomach and colon.Neurogastroenterology and motility · 2011Article
- The aging colon: the role of enteric neurodegeneration in constipation.Current gastroenterology reports · 2010Review
- Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo.Neurogastroenterology and motility · 2010Article
- Distribution, development and proliferation of interstitial cells of Cajal in murine colon: an immunohistochemical study from neonatal to adult life.Histochemistry and cell biology · 2010Article
- Extending the knowledge in histochemistry and cell biology.Histochemistry and cell biology · 2010Review
- Physiology, injury, and recovery of interstitial cells of Cajal: basic and clinical science.Gastroenterology · 2009Review
- Myometrial interstitial cells and the coordination of myometrial contractility.Journal of cellular and molecular medicine · 2009Review
- Apoptosis of interstitial cells of Cajal, smooth muscle cells, and enteric neurons induced by intestinal ischemia and reperfusion injury in adult guinea pigs.Virchows Archiv : an international journal of pathology · 2009Article
- A distinct type of cell in myocardium: interstitial Cajal-like cells (ICLCs).Journal of cellular and molecular medicine · 2009Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper aimed at investigating the alterations in interstitial cells of Cajal (ICCs) in the murine small intestine from 0-day to 56-day post-partum (P0-P56) by immunohistochemistry. The Kit+ ICCs, which were situated around myenteric nerve plexus (ICC-MY) formed a loose cellular network at P0 which changed into an intact one before P32. The density of ICC-MY increased from P0 to P12, and then decreased until P32. In contrast, the estimated total amount increased more than 15-fold at P32 than that at P0. Some Kit+/BrdU+ cells were observed at 24 h after one BrdU injection to the different-aged mice, and the number decreased from P2 to P24 and vanished at P32. Actually a few Kit+/BrdU+ cells can be observed at 1 h after one BrdU injection at P10, and the amount doubled at 24 h along with paired Kit+/BrdU+ cells. A number of BrdU+ ICCs were also labeled with CD34, CD44 and insulin-like growth factor I receptor. About 65% ICCs were BrdU+ at P32 after daily BrdU injection from P0. Our results indicate that an age-dependent proliferation is involved in the postnatal development of ICC-MY which increase greatly in cell numbers and proliferative ICCs may originate from ICCs progenitor cells.
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Registered trials
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