ArticleThe Journal of biological chemistry2008
Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- PKCeta Promotes Stress-Induced Autophagy and Senescence in Breast Cancer Cells, Presenting a Target for Therapy.Pharmaceutics · 2022Article
- Review
- Phosphorylation Modifications Regulating Cardiac Protein Quality Control Mechanisms.Frontiers in physiology · 2020Review
- Autophagy in hypoxic ovary.Cellular and molecular life sciences : CMLS · 2019Review
- Activated kinase screening identifies theAutophagy · 2019Article
- The roles of PKCs in regulating autophagy.Journal of cancer research and clinical oncology · 2018Review
- Interplay between FGFR2b-induced autophagy and phagocytosis: role of PLCγ-mediated signalling.Journal of cellular and molecular medicine · 2018Article
- Determination of Brain-Regional Blood Perfusion and Endogenous cPKCγ Impact on Ischemic Vulnerability of Mice with Global Ischemia.Neurochemical research · 2017Article
- Review
- Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver.Diabetes · 2016Article
- Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi.The Journal of biological chemistry · 2015Article
- Ethambutol induces impaired autophagic flux and apoptosis in the rat retina.Disease models & mechanisms · 2015Article
- Article
- Autophagy: regulation and role in development.Autophagy · 2013Review
- 14-3-3 Proteins are Regulators of Autophagy.Cells · 2012Article
- Identification of an AAA ATPase VPS4B-dependent pathway that modulates epidermal growth factor receptor abundance and signaling during hypoxia.Molecular and cellular biology · 2012Article
- Article
- Regulation of Ca²⁺ release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Regulation of autophagy by kinases.Cancers · 2011Article
- Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae.The Journal of cell biology · 2011Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Macroautophagy, a tightly orchestrated intracellular process for bulk degradation of cytoplasmic proteins or organelles, is believed to be essential for cell survival or death in response to stress conditions. Recent observations indicate that autophagy is an adaptive response in cells subjected to prolonged hypoxia. However, the signaling mechanisms that activate autophagy under acute hypoxic stress are not clearly understood. In this study, we show that acute hypoxic stress by treatment with 1% O(2) or desferroxamine, a hypoxia-mimetic agent, of cells renders a rapid induction of LC3-II level changes and green fluorescent protein-LC3 puncta accumulation, hallmarks of autophagic processing, and that this process involves protein kinase Cdelta (PKCdelta), and occurs prior to the induction of BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3). Interestingly, hypoxic stress leads to a rapid and transient activation of JNK in Pa-4 or mouse embryo fibroblast cells. Acute hypoxic stress-induced changes in LC3-II level and JNK activation are attenuated in Pa-4 cells by dominant negative PKCdeltaKD or in mouse embryo fibroblast/PKCdelta-null cells. Intriguingly, the requirement of PKCdelta is not apparent for starvation-induced autophagy. The importance of PKCdelta in hypoxic stress-induced adaptive responses is further supported by our findings that inhibition of PKCdelta-facilitated autophagy by 3-methyladenine or Atg5 knock-out renders a greater prevalence of cell death following prolonged desferroxamine treatment, whereas PKCdelta- or JNK1-deficient cells exhibit resistance to extended hypoxic exposure. These results uncover dual roles of PKCdelta-dependent signaling in the cell fate determination upon hypoxic exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.