ArticleInvestigative ophthalmology & visual science2009
Histamine enhances voltage-gated potassium currents of ON bipolar cells in macaque retina.
Article in Investigative ophthalmology & visual science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- The central histaminergic system slows visual processing in the retina and lateral geniculate nucleus of awake mice.PLoS biology · 2025Article
- Top-down modulation of the retinal code via histaminergic neurons of the hypothalamus.Science advances · 2024Article
- Novel Insight of Histamine and Its Receptor Ligands in Glaucoma and Retina Neuroprotection.Biomolecules · 2021Review
- Histaminergic Control of Corticostriatal Synaptic Plasticity during Early Postnatal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Schizophrenia and the retina: Towards a 2020 perspective.Schizophrenia research · 2020Article
- Sensory Integration: Cross-Modal Communication Between the Olfactory and Visual Systems in Zebrafish.Chemical senses · 2019Review
- The Effect of Histamine on Inward and Outward Currents in Mouse Retinal Amacrine Cells.Cellular and molecular neurobiology · 2018Article
- Efferent influences on the bioelectrical activity of the retina in primates.Documenta ophthalmologica. Advances in ophthalmology · 2017Review
- Histamine receptors of cones and horizontal cells in Old World monkey retinas.The Journal of comparative neurology · 2012Article
- Histamine elevates free intracellular calcium in mouse retinal dopaminergic cells via H1-receptors.Investigative ophthalmology & visual science · 2011Article
- Histamine reduces flash sensitivity of on ganglion cells in the primate retina.Investigative ophthalmology & visual science · 2010Article
- Differential expression of three T-type calcium channels in retinal bipolar cells in rats.Visual neuroscienceArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe goal was to understand the functions of retinopetal axons containing histamine. In prior work, type 3 histamine receptors (HR3) have been localized to the tips of ON bipolar cell dendrites in macaque retinas. Voltage-gated potassium channels have also been localized to bipolar cell dendrites, and the hypothesis tested in the present study was that these are modulated by histamine.
methodsWhole-cell recordings of potassium currents were made from bipolar cells in slice preparations of macaque retina. In voltage-clamp mode, the cells were held at -60 mV and stepped to values from -60 to 80 mV. Recordings of the membrane potential were also made in current-clamp mode. Histamine, the HR3 agonist (R) alpha-methylhistamine (RAMH), tetraethyl ammonium (TEA), and 4-aminopyridine (4-AP) were applied in the superfusate.
resultsHistamine produced a dose-dependent increase in potassium currents in a subset of bipolar cells. At 5 microM, histamine increased the currents by 15% or more in the ON bipolar cells but not in the OFF bipolar cells. RAMH at 5 microM increased the amplitude of the potassium currents in the ON bipolar cells. In 10 mM TEA, potassium currents were reduced in all the bipolar cells, and there was no effect of histamine. Histamine hyperpolarized the resting membrane potential of the ON bipolar cells by 5 mV.
conclusionsBy enhancing potassium currents in the ON bipolar cells, histamine is expected to reduce the amplitude of the light responses and limit their duration. The hyperpolarization of the resting membrane potential would also reduce neurotransmitter release at their output synapses.
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