ArticleProceedings of the National Academy of Sciences of the United States of America2008
A genetic timer through noise-induced stabilization of an unstable state.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Independent control of mean and noise by convolution of gene expression distributions.Nature communications · 2021Article
- A tunable population timer in multicellular consortia.iScience · 2021Article
- Theoretical study of the impact of adaptation on cell-fate heterogeneity and fractional killing.Scientific reports · 2020Article
- Synaptic mechanisms for motor variability in a feedforward network.Science advances · 2020Article
- Robust stochastic Turing patterns in the development of a one-dimensional cyanobacterial organism.PLoS biology · 2018Article
- Computing with biological switches and clocks.Natural computing · 2018Article
- Role of noise and parametric variation in the dynamics of gene regulatory circuits.NPJ systems biology and applications · 2018Article
- Effects of cell cycle noise on excitable gene circuits.Physical biology · 2016Article
- Genetic Redundancies Enhance Information Transfer in Noisy Regulatory Circuits.PLoS computational biology · 2016Article
- Transitions in a genetic transcriptional regulatory system under Lévy motion.Scientific reports · 2016Article
- A Statistical Approach Reveals Designs for the Most Robust Stochastic Gene Oscillators.ACS synthetic biology · 2016Article
- Intrinsic noise induces critical behavior in leaky Markovian networks leading to avalanching.PLoS computational biology · 2014Article
- Functional tunability of biological circuits from additional toggle switches.IET systems biology · 2013Article
- The role of feedback control mechanisms on the establishment of oscillatory regimes in the Ras/cAMP/PKA pathway in S. cerevisiae.EURASIP journal on bioinformatics & systems biology · 2012Article
- The transition between stochastic and deterministic behavior in an excitable gene circuit.PloS one · 2012Article
- Article
- Biological role of noise encoded in a genetic network motif.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Switchable genetic oscillator operating in quasi-stable mode.Journal of the Royal Society, Interface · 2010Article
- Avoiding transcription factor competition at promoter level increases the chances of obtaining oscillation.BMC systems biology · 2010Article
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Authors and funding
3 authors.
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Abstract
Stochastic fluctuations affect the dynamics of biological systems. Typically, such noise causes perturbations that can permit genetic circuits to escape stable states, triggering, for example, phenotypic switching. In contrast, studies have shown that noise can surprisingly also generate new states, which exist solely in the presence of fluctuations. In those instances noise is supplied externally to the dynamical system. Here, we present a mechanism in which noise intrinsic to a simple genetic circuit effectively stabilizes a deterministically unstable state. Furthermore, this noise-induced stabilization represents a unique mechanism for a genetic timer. Specifically, we analyzed the effect of noise intrinsic to a prototypical two-component gene-circuit architecture composed of interacting positive and negative feedback loops. Genetic circuits with this topology are common in biology and typically regulate cell cycles and circadian clocks. These systems can undergo a variety of bifurcations in response to parameter changes. Simulations show that near one such bifurcation, noise induces oscillations around an unstable spiral point and thus effectively stabilizes this unstable fixed point. Because of the periodicity of these oscillations, the lifetime of the noise-dependent stabilization exhibits a polymodal distribution with multiple, well defined, and regularly spaced peaks. Therefore, the noise-induced stabilization presented here constitutes a minimal mechanism for a genetic circuit to function as a timer that could be used in the engineering of synthetic circuits.
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