ArticleDiabetes2009
Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR).
Article in Diabetes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies.Cardiovascular diabetology · 2012Pooled it
- Association of Baseline Factors With Glycemic Outcomes in GRADE: A Comparative Effectiveness Randomized Clinical Trial.Diabetes care · 2024 · on this mapTrial
- Genetic landscape of Gullah African Americans.American journal of physical anthropology · 2021Article
- Genetics of Type 2 Diabetes in African Americans.Current diabetes reports · 2015Review
- Cardiovascular risk in Gullah African Americans with high familial risk of type 2 diabetes mellitus: project SuGAR.Southern medical journal · 2014Article
- Genetic variation and adaptation in Africa: implications for human evolution and disease.Cold Spring Harbor perspectives in biology · 2014Review
- Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry.The Journal of rheumatology · 2013Article
- Successes, Challenges and Lessons Learned: Community-engaged research with South Carolina's Gullah population.Gateways : international journal of community research & engagement · 2013Article
- Type 2 diabetes associated changes in the plasma non-esterified fatty acids, oxylipins and endocannabinoids.PloS one · 2012Article
- Article
- Beyond the medical model: interdisciplinary programs of community-engaged health research.Clinical and translational science · 2011Article
- Pleiotropy of type 2 diabetes with obesity.Journal of human genetics · 2011Article
- Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women.PloS one · 2010Article
- Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2010Article
- Enhancing recruitment of African-American families into genetic research: lessons learned from Project SuGar.Journal of community genetics · 2010Article
- The genetic architecture of lipoprotein subclasses in Gullah-speaking African American families enriched for type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR).Journal of lipid research · 2010Article
- Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy.BMC medical genetics · 2010Article
- Oral health knowledge and behavior among adults with diabetes.Diabetes research and clinical practice · 2009Article
- Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.The Journal of nutrition · 2009Article
- Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe Gullah-speaking African American population from the Sea Islands of South Carolina is characterized by a low degree of European admixture and high rates of type 2 diabetes and diabetic complications. Affected relative pairs with type 2 diabetes were recruited through the Sea Islands Genetic African American Registry (Project SuGAR). RESEARCH DESIGN AND
methodsWe conducted a genome-wide linkage scan, genotyping 5,974 single nucleotide polymorphisms in 471 affected subjects and 50 unaffected relatives from 197 pedigrees. Data were analyzed using a multipoint engine for rapid likelihood inference and ordered subsets analyses (OSAs) for age at type 2 diabetes diagnosis, waist circumference, waist-to-hip ratio, and BMI. We searched for heterogeneity and interactions using a conditional logistic regression likelihood approach.
resultsLinkage peaks on chromosome 14 at 123-124 cM were detected for type 2 diabetes (logarithm of odds [LOD] 2.10) and for the subset with later age at type 2 diabetes diagnosis (maximum LOD 4.05). Two linkage peaks on chromosome 7 were detected at 44-45 cM for type 2 diabetes (LOD 1.18) and at 78 cM for type 2 diabetes (LOD 1.64) and the subset with earlier age at type 2 diabetes diagnosis (maximum LOD 3.93). The chromosome 14 locus and a peak on 7p at 29.5 cM were identified as important in the multilocus model. Other regions that provided modest evidence for linkage included chromosome 1 at 167.5 cM (LOD 1.51) and chromosome 3 at 121.0 cM (LOD 1.61).
conclusionsThis study revealed a novel type 2 diabetes locus in an African American population on 14q that appears to reduce age of disease onset and confirmed two loci on chromosome 7.
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