ArticleAmerican journal of physiology. Heart and circulatory physiology2008
PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase.
Article in American journal of physiology. Heart and circulatory physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 72 citations in OpenAlex.
- Circadian regulation of cardiovascular function: from physiology to clinical implications.Genome medicine · 2026Review
- Circadian clock genes and insomnia: molecular mechanisms and therapeutic implications.Annals of medicine · 2025Review
- Factors influencing heart rate variability in nurses following night shifts: a prospective observational clinical study.BMC nursing · 2025Article
- Decoding Multifaceted Roles of Sleep-Related Genes as Molecular Bridges in Chronic Disease Pathogenesis.International journal of molecular sciences · 2025Review
- Heart rate and heart rate variability following sleep deprivation in retired night shift workers and retired day workers.Psychophysiology · 2023Article
- Circadian and homeostatic sleep-wake regulation of secretory immunoglobulin A (sIgA): Effects of environmental light and recovery sleep.Brain, behavior, & immunity - health · 2022Article
- Predicting and mitigating fatigue effects due to sleep deprivation: A review.Frontiers in neuroscience · 2022Review
- Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.Comprehensive Physiology · 2021Review
- Circadian PERformance in breast cancer: a germline and somatic genetic study of PER3NPJ breast cancer · 2021Article
- Associations of PER3 polymorphisms with clopidogrel resistance among Chinese Han people treated with clopidogrel.Journal of clinical laboratory analysis · 2021Article
- Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1.Cellular and molecular life sciences : CMLS · 2021Review
- Altered Expression of Circadian Clock Genes in Patients with Atrial Fibrillation Is Associated with Atrial High-Rate Episodes and Left Atrial Remodeling.Diagnostics (Basel, Switzerland) · 2021Article
- Autonomic Modulation During Baseline and Recovery Sleep in Adult Sleepwalkers.Frontiers in neurology · 2021Article
- Heart rate variability rebound following exposure to persistent and repetitive sleep restriction.Sleep · 2019Article
- Neurobehavioral Effects and Biomarkers of Sleep Loss in Healthy Adults.Current neurology and neuroscience reports · 2017Review
- Sleep Deprivation in Young and Healthy Subjects Is More Sensitively Identified by Higher Frequencies of Electrodermal Activity than by Skin Conductance Level Evaluated in the Time Domain.Frontiers in physiology · 2017Article
- A PER3 Polymorphism Interacts with Sleep Duration to Influence Transient Mood States in Women.Journal of circadian rhythms · 2016Article
- Circadian rhythm genes CLOCK and PER3 polymorphisms and morning gastric motility in humans.PloS one · 2015Article
- Bright light therapy for depression: a review of its effects on chronobiology and the autonomic nervous system.Chronobiology international · 2014Review
- Quantitative electroencephalography and behavioural correlates of daytime sleepiness in chronic stroke.BioMed research international · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A variable number tandem repeat polymorphism in the coding region of the circadian clock PERIOD3 (PER3) gene has been shown to affect sleep. Because circadian rhythms and sleep are known to modulate sympathovagal balance, we investigated whether homozygosity for this PER3 polymorphism is associated with changes in autonomic nervous system (ANS) activity during sleep and wakefulness at baseline and after sleep deprivation. Twenty-two healthy participants were selected according to their PER3 genotype. ANS activity, evaluated by heart rate (HR) and HR variability (HRV) indexes, was quantified during baseline sleep, a 40-h period of wakefulness, and recovery sleep. Sleep deprivation induced an increase in slow-wave sleep (SWS), a decrease in the global variability, and an unbalance of the ANS with a loss of parasympathetic predominance and an increase in sympathetic activity. Individuals homozygous for the longer allele (PER3(5/5)) had more SWS, an elevated sympathetic predominance, and a reduction of parasympathetic activity compared with PER3(4/4), in particular during baseline sleep. The effects of genotype were strongest during non-rapid eye movement (NREM) sleep and absent or much smaller during REM sleep. The NREM-REM cycle-dependent modulation of the low frequency-to-(low frequency + high frequency) ratio was diminished in PER3(5/5) individuals. Circadian phase modulated HR and HRV, but no interaction with genotype was observed. In conclusion, the PER3 polymorphism affects the sympathovagal balance in cardiac control in NREM sleep similar to the effect of sleep deprivation.
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