ArticleBiophysical journal2008
Membrane thickening by the antimicrobial peptide PGLa.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 75 citations in OpenAlex.
- Uncovering Key Characteristics of Antibacterial Peptides through Machine Learning.Macromolecular rapid communications · 2026Article
- Predicting peptide orientation in membrane interactions: a review on transmembrane and surface-bound states.European biophysics journal : EBJ · 2026Review
- Peptide-Based Biomaterials for Combatting Infections and Improving Drug Delivery.Pharmaceutics · 2024Review
- Molecular and energetic analysis of the interaction and specificity of Maximin 3 with lipid membranes: In vitro and in silico assessments.Protein science : a publication of the Protein Society · 2024Article
- Antimicrobial Peptides Increase Line Tension in Raft-Forming Lipid Membranes.Journal of the American Chemical Society · 2024Article
- A new look at Hsp70 activity in phosphatidylserine-enriched membranes: chaperone-induced quasi-interdigitated lipid phase.Scientific reports · 2023Article
- Effects of a Semisynthetic Catechin on Phosphatidylglycerol Membranes: A Mixed Experimental and Simulation Study.Molecules (Basel, Switzerland) · 2023Article
- Small-Angle Neutron Scattering for Studying Lipid Bilayer Membranes.Biomolecules · 2022Review
- Bridging the Antimicrobial Activity of Two Lactoferricin Derivatives inFrontiers in medical technology · 2021Article
- Review
- Effects of artepillin C on model membranes displaying liquid immiscibility.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions.Frontiers in microbiology · 2019Review
- Influence of Acyl Chain Saturation on the Membrane-Binding Activity of a Short Antimicrobial Peptide.ACS omega · 2017Article
- Interaction of Artepillin C with model membranes.European biophysics journal : EBJ · 2017Article
- Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Membrane Thinning and Thickening Induced by Membrane-Active Amphipathic Peptides.Frontiers in cell and developmental biology · 2016Article
- Membrane permeation induced by aggregates of human islet amyloid polypeptides.Biophysical journal · 2013Article
- Simulating the mechanism of antimicrobial lipopeptides with all-atom molecular dynamics.Biochemistry · 2013Article
- Article
- On the role of NMR spectroscopy for characterization of antimicrobial peptides.Methods in molecular biology (Clifton, N.J.) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Using x-ray diffraction, solid-state 2H-NMR, differential scanning calorimetry, and dilatometry, we have observed a perturbation of saturated acyl chain phosphatidylglycerol bilayers by the antimicrobial peptide peptidyl-glycylleucine-carboxyamide (PGLa) that is dependent on the length of the hydrocarbon chain. In the gel phase, PGLa induces a quasi-interdigitated phase, previously reported also for other peptides, which is most pronounced for C18 phosphatidylglycerol. In the fluid phase, we found an increase of the membrane thickness and NMR order parameter for C14 and C16 phosphatidylglycerol bilayers, though not for C18. The data is best understood in terms of a close hydrophobic match between the C18 bilayer core and the peptide length when PGLa is inserted with its helical axis normal to the bilayer surface. The C16 acyl chains appear to stretch to accommodate PGLa, whereas tilting within the bilayer seems to be energetically favorable for the peptide when inserted into bilayers of C14 phosphatidylglycerol. In contrast to the commonly accepted membrane thinning effect of antimicrobial peptides, the data demonstrate that pore formation does not necessarily relate to changes in the overall bilayer structure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.