ReviewCardiovascular research2009
Macro- and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium.
Review in Cardiovascular research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01182376 (SOAR), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SOAR: Study Observing Antiarrhythmic Remodelling Using LGE-MRI
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials.BMJ open · 2018Pooled it
- The Relationship between Serum Zinc Level and Heart Failure: A Meta-Analysis.BioMed research international · 2018Pooled it
- Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study.Journal of the American College of Cardiology · 2016Trial
- Identification of novel biomarkers for hypertension and ventricular remodeling based on transcriptomics and machine learning.iScience · 2025Article
- Vitamin D-Parathyroid Hormone-Fibroblast Growth Factor 23 Axis and Cardiac Remodeling.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025Review
- An Overexpression of SLC30A6 Gene Contributes to Cardiomyocyte Dysfunction via Affecting Mitochondria and Inducing Activations in K-Acetylation and Epigenetic Proteins.Biochemical genetics · 2024Article
- Low Vitamin D Levels Are Associated with Increased Cardiac Iron Uptake in Beta-Thalassemia Major.Diagnostics (Basel, Switzerland) · 2023Article
- Is Hypovitaminosis D a Risk Factor for Heart Failure?Life (Basel, Switzerland) · 2023Review
- Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease.International journal of molecular sciences · 2021Review
- Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo.International journal of environmental research and public health · 2021Article
- The effect of vitamin D therapy in the improvement of cardiac performance and exercise capacity in patients with heart failure: A double-blind, randomized, placebo-controlled trial.ARYA atherosclerosis · 2021Article
- Article
- Ionomic profiling of pericardial fluid in ischemic heart disease.RSC advances · 2020Article
- Effects of Vitamin D on Left Ventricular Ejection Fraction in Patients with Systolic Heart Failure: A Double-Blind Randomized Clinical Trial.International journal of endocrinology and metabolism · 2020Article
- Zinc Deficiency as a Reversible Cause of Heart Failure.Texas Heart Institute journal · 2020Article
- Review
- Vitamin D Deficiency Predicts Poor Clinical Outcomes in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy.Disease markers · 2019Observational
- Vitamin D measurement and effect on outcome in a cohort of patients with heart failureEndocrine connections · 2018Article
- Selenium, Vanadium, and Chromium as Micronutrients to Improve Metabolic Syndrome.Current hypertension reports · 2017Review
- Dietary calcium and Framingham Risk Score in vitamin D deficient male (KNHANES 2009-2011).Yonsei medical journal · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Hypertension and heart failure are worldwide health problems of ever-increasing proportions. A failure of the heart, during either systolic and/or diastolic phases of the cardiac cycle, has its origins rooted in an adverse structural, biochemical, and molecular remodelling of myocardium that involves its cellular constituents, extracellular matrix, and intramural coronary vasculature. Herein we focus on the pathogenic role of a dyshomeostasis of several macro- (i.e. Ca(2+) and Mg(2+)) and micronutrients (i.e. Zn(2+), Se(2+), and vitamin D) in contributing to adverse remodelling of the myocardium and its failure as a pulsatile muscular pump. An improved understanding of how these macro- and micronutrients account for the causes and consequences of adverse myocardial remodelling carries with it the potential of identifying new biomarkers predictive of risk, onset and progression, and response to intervention(s), which could be monitored non-invasively and serially over time. Moreover, such incremental knowledge will serve as the underpinning to the development of novel strategies aimed at preventing and/or regressing the ongoing adverse remodelling of myocardium. The time is at hand to recognize the importance of macro- and micronutrient dyshomeostasis in the evaluation and management of hypertension and heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.