Evidence map›Paper›PMID 18835662›Full record

Trial reportPsychoneuroendocrinology2009

Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress.

Thaddeus W W Pace, Lobsang Tenzin Negi, Daniel D Adame, Steven P Cole, Teresa I Sivilli, Timothy D Brown, Michael J Issa, Charles L Raison

4 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychoneuroendocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 192 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed, 15 pooled it
23.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02163941 phase1completednot on this mapstarted 2014, after this paper: background citation

Meditation Training for Emotional Numbing in Post-traumatic Stress Disorder

TypeinterventionalSponsorEmory UniversityRan2014 to 2016Enrolled20ConditionsProlonged Post-traumatic Stress DisorderArmsCompassion Training
NCT03305952 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Cognitively-Based Compassion Training (CBCT) for the Improvement of Health Related Quality of Life, Fear of Illness Recurrence, Compassion and Self-compassion in Breast Cancer Survivors Sample

TypeinterventionalSponsorUniversity of ValenciaRan2016 to 2018Enrolled72ConditionsCompassion, Treatment as UsualArmsCBCT, TAU
NCT03674749 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Effect of Meditation and Hyperbaric Oxygen Therapy on Cognition, Healing Process and Overall Well-being in Elderly Patients With Chronic Wounds

TypeinterventionalSponsorUniversity Health Network, TorontoRan2018 to 2020Enrolled50ConditionsWoundArmsMeditation and Hyperbaric Oxygen Treament
NCT05083091 nacompletednot on this mapstarted 2022, after this paper: background citation

Smartphone Stress Management Training for Irritable Bowel Syndrome

TypeinterventionalSponsorCarnegie Mellon UniversityRan2022 to 2025Enrolled359ConditionsIrritable Bowel SyndromeArmsMindfulness and Attention Training, Mindfulness training, Coping Condition
3 · Its place in the literature

Who cites it

192 citing papers in PubMed, 15 syntheses or guidelines pooled it, 745 citations in OpenAlex.

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  6. Psychological interventions to foster resilience in healthcare students.The Cochrane database of systematic reviews · 2020
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  10. Guideline
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  12. Psychological therapies for children and adolescents exposed to trauma.The Cochrane database of systematic reviews · 2016
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132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Thaddeus W W PaceDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365C Clifton Road, Atlanta, GA 30322, USA.
Lobsang Tenzin Negi
Daniel D Adame
Steven P Cole
Teresa I Sivilli
Timothy D Brown
Michael J Issa
Charles L Raison
Emory and Henry College · USCornell University · USEmory University · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
X LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI BRANN, ALFRED W · 1985 to 2007
$21.3M
Glucocorticoid Resistance in Immune-Based DepressionK23MH064619 · NIMH · EMORY UNIVERSITY · PI RAISON, CHARLES · 2002 to 2006
$648k
NCATS NIH HHS UL1 TR000454NCRR NIH HHS M01 RR000039NCRR NIH HHS M01 RR0039NCRR NIH HHS UL1 RR025008NIMH NIH HHS K23 MH064619
6 · The paper itself

Abstract

Meditation practices may impact physiological pathways that are modulated by stress and relevant to disease. While much attention has been paid to meditation practices that emphasize calming the mind, improving focused attention, or developing mindfulness, less is known about meditation practices that foster compassion. Accordingly, the current study examined the effect of compassion meditation on innate immune, neuroendocrine and behavioral responses to psychosocial stress and evaluated the degree to which engagement in meditation practice influenced stress reactivity. Sixty-one healthy adults were randomized to 6 weeks of training in compassion meditation (n=33) or participation in a health discussion control group (n=28) followed by exposure to a standardized laboratory stressor (Trier social stress test [TSST]). Physiologic and behavioral responses to the TSST were determined by repeated assessments of plasma concentrations of interleukin (IL)-6 and cortisol as well as total distress scores on the Profile of Mood States (POMS). No main effect of group assignment on TSST responses was found for IL-6, cortisol or POMS scores. However, within the meditation group, increased meditation practice was correlated with decreased TSST-induced IL-6 (r(p)=-0.46, p=0.008) and POMS distress scores (r(p)=-0.43, p=0.014). Moreover, individuals with meditation practice times above the median exhibited lower TSST-induced IL-6 and POMS distress scores compared to individuals below the median, who did not differ from controls. These data suggest that engagement in compassion meditation may reduce stress-induced immune and behavioral responses, although future studies are required to determine whether individuals who engage in compassion meditation techniques are more likely to exhibit reduced stress reactivity.

Indexed as

EmpathyAdolescentFemaleHumansHydrocortisoneImmunity, InnateInterleukin-6MaleMeditationStress, PhysiologicalStress, PsychologicalTime FactorsYoung AdultHydrocortisoneInterleukin-6

Identifiers

PMID18835662
PMCPMC2695992
OpenAlexW2101119621

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.