ArticleJournal of structural biology2008
Three-dimensional geometric modeling of membrane-bound organelles in ventricular myocytes: bridging the gap between microscopic imaging and mathematical simulation.
Article in Journal of structural biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- An Open-Source Mesh Generation Platform for Biophysical Modeling Using Realistic Cellular Geometries.Biophysical journal · 2020Article
- The Implementation of the Colored Abstract Simplicial Complex and its Application to Mesh Generation.ACM transactions on mathematical software. Association for Computing Machinery · 2019Article
- Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology.Journal of visualized experiments : JoVE · 2018Article
- 3D membrane segmentation and quantification of intact thick cells using cryo soft X-ray transmission microscopy: A pilot study.PloS one · 2017Article
- Nanoscale three-dimensional imaging of the human myocyte.Journal of structural biology · 2014Article
- Computational modeling of subcellular transport and signaling.Current opinion in structural biology · 2014Review
- The transverse-axial tubular system of cardiomyocytes.Cellular and molecular life sciences : CMLS · 2013Review
- Multiscale geometric modeling of macromolecules II: Lagrangian representation.Journal of computational chemistry · 2013Article
- Decoding myocardial Ca²⁺ signals across multiple spatial scales: a role for sensitivity analysis.Journal of molecular and cellular cardiology · 2013Review
- Geometric modeling of subcellular structures, organelles, and multiprotein complexes.International journal for numerical methods in biomedical engineering · 2012Article
- Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit.The Journal of physiology · 2012Article
- Multiscale modeling of calcium dynamics in ventricular myocytes with realistic transverse tubules.IEEE transactions on bio-medical engineering · 2011Article
- Quality Mesh Smoothing via Local Surface Fitting and Optimum Projection.Graphical models · 2011Article
- SynapticDB, effective web-based management and sharing of data from serial section electron microscopy.Neuroinformatics · 2011Article
- Delta-sarcoglycan gene therapy halts progression of cardiac dysfunction, improves respiratory failure, and prolongs life in myopathic hamsters.Circulation. Heart failure · 2011Article
- Numerical analysis of Ca2+ signaling in rat ventricular myocytes with realistic transverse-axial tubular geometry and inhibited sarcoplasmic reticulum.PLoS computational biology · 2010Article
- Control of Ca2+ release by action potential configuration in normal and failing murine cardiomyocytes.Biophysical journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
A general framework of image-based geometric processing is presented to bridge the gap between three-dimensional (3D) imaging that provides structural details of a biological system and mathematical simulation where high-quality surface or volumetric meshes are required. A 3D density map is processed in the order of image pre-processing (contrast enhancement and anisotropic filtering), feature extraction (boundary segmentation and skeletonization), and high-quality and realistic surface (triangular) and volumetric (tetrahedral) mesh generation. While the tool-chain described is applicable to general types of 3D imaging data, the performance is demonstrated specifically on membrane-bound organelles in ventricular myocytes that are imaged and reconstructed with electron microscopic (EM) tomography and two-photon microscopy (T-PM). Of particular interest in this study are two types of membrane-bound Ca(2+)-handling organelles, namely, transverse tubules (T-tubules) and junctional sarcoplasmic reticulum (jSR), both of which play an important role in regulating the excitation-contraction (E-C) coupling through dynamic Ca(2+) mobilization in cardiomyocytes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.