ArticleLangmuir : the ACS journal of surfaces and colloids2009
Block liposomes from curvature-stabilizing lipids: connected nanotubes, -rods, or -spheres.
Article in Langmuir : the ACS journal of surfaces and colloids, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Cryo-TEM Reveals the Influence of Multivalent Charge and PEGylation on Shape Transitions in Fluid Lipid Assemblies: From Vesicles to Discs, Rods, and Spheres.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Nonaxisymmetric Shapes of Biological Membranes from Locally Induced Curvature.Biophysical journal · 2020Article
- PEGylation of Paclitaxel-Loaded Cationic Liposomes Drives Steric Stabilization of Bicelles and Vesicles thereby Enhancing Delivery and Cytotoxicity to Human Cancer Cells.ACS applied materials & interfaces · 2020Article
- Placing and shaping liposomes with reconfigurable DNA nanocages.Nature chemistry · 2017Article
- The effect of multivalent cations and Tau on paclitaxel-stabilized microtubule assembly, disassembly, and structure.Advances in colloid and interface science · 2016Review
- Lipopolysaccharide-induced dynamic lipid membrane reorganization: tubules, perforations, and stacks.Biophysical journal · 2014Article
- Transformation of taxol-stabilized microtubules into inverted tubulin tubules triggered by a tubulin conformation switch.Nature materials · 2014Article
- Cytochrome c causes pore formation in cardiolipin-containing membranes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Nanoscale assembly in biological systems: from neuronal cytoskeletal proteins to curvature stabilizing lipids.Advanced materials (Deerfield Beach, Fla.) · 2011Review
- Single vesicle observations of the cardiolipin-cytochrome C interaction: induction of membrane morphology changes.Langmuir : the ACS journal of surfaces and colloids · 2011Article
- Block Liposome and Nanotube Formation is a General Phenomenon of Two-Component Membranes Containing Multivalent Lipids.Soft matter · 2011Article
- Cationic liposome-nucleic acid complexes for gene delivery and silencing: pathways and mechanisms for plasmid DNA and siRNA.Topics in current chemistry · 2010Review
- The effect of salt and pH on block liposomes studied by cryogenic transmission electron microscopy.Biochimica et biophysica acta · 2009Article
- Liquid crystalline phases of dendritic lipid-DNA self-assemblies: lamellar, hexagonal, and DNA bundles.The journal of physical chemistry. B · 2009Article
- Block liposomes vesicles of charged lipids with distinctly shaped nanoscale sphere-, pear-, tube-, or rod-segments.Methods in enzymology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We report on the discovery of block liposomes, a new class of chain-melted (liquid) vesicles, with membranes comprised of mixtures of the membrane-curvature-stabilizing multivalent lipid MVLBG2 of colossal charge +16 e and neutral 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC). In a narrow MVLBG2 composition range (8-10 mol%), cryo-TEM revealed block liposomes consisting of distinctly shaped, yet connected, nanoscale spheres, pears, tubes, or rods. Unlike typical liposome systems, where spherical vesicles, tubular vesicles, and cylindrical micelles are separated on the macroscopic scale, within a block liposome, shapes are separated on the nanometer scale. Diblock (pear-tube) and triblock (pear-tube-pear) liposomes contain nanotubes with inner lumen diameter of 10-50 nm. Diblock (sphere-rod) liposomes were found to contain micellar nanorods approximately 4 nm in diameter and several micrometers in length, analogous to cytoskeletal filaments of eukaryotic cells. Block liposomes may find a range of applications in chemical and nucleic acid delivery and as building blocks in the design of templates for hierarchical structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.