ArticlePLoS genetics2008
Mutation and evolutionary rates in adélie penguins from the antarctic.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 170 citations in OpenAlex.
- Review
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- Ancient and Modern Genomes Reveal Microsatellites Maintain a Dynamic Equilibrium Through Deep Time.Genome biology and evolution · 2024Article
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- Emerging biological archives can reveal ecological and climatic change in Antarctica.Global change biology · 2022Review
- Advanced age increases frequencies of de novo mitochondrial mutations in macaque oocytes and somatic tissues.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The genome of the Paleogene relic tree Bretschneidera sinensis: insights into trade-offs in gene family evolution, demographic history, and adaptive SNPs.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- A short scan of Māori journeys to Antarctica.Journal of the Royal Society of New Zealand · 2022Article
- Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues.PLoS biology · 2020Article
- Pronounced somatic bottleneck in mitochondrial DNA of human hair.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Bottleneck and selection in the germline and maternal age influence transmission of mitochondrial DNA in human pedigrees.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Uncovering population structure in the Humboldt penguin (Spheniscus humboldti) along the Pacific coast at South America.PloS one · 2019Article
- Varied Mechanisms and Models for the Varying Mitochondrial Bottleneck.Frontiers in cell and developmental biology · 2019Article
- Contrasting phylogeographic pattern among Eudyptes penguins around the Southern Ocean.Scientific reports · 2018Article
- Chinstrap penguin population genetic structure: one or more populations along the Southern Ocean?BMC evolutionary biology · 2018Article
- A comparison of methods for estimating substitution rates from ancient DNA sequence data.BMC evolutionary biology · 2018Article
- Article
- The rate and potential relevance of new mutations in a colonizing plant lineage.PLoS genetics · 2018Article
- Review
- Contrasting responses to a climate regime change by sympatric, ice-dependent predators.BMC evolutionary biology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Precise estimations of molecular rates are fundamental to our understanding of the processes of evolution. In principle, mutation and evolutionary rates for neutral regions of the same species are expected to be equal. However, a number of recent studies have shown that mutation rates estimated from pedigree material are much faster than evolutionary rates measured over longer time periods. To resolve this apparent contradiction, we have examined the hypervariable region (HVR I) of the mitochondrial genome using families of Adélie penguins (Pygoscelis adeliae) from the Antarctic. We sequenced 344 bps of the HVR I from penguins comprising 508 families with 915 chicks, together with both their parents. All of the 62 germline heteroplasmies that we detected in mothers were also detected in their offspring, consistent with maternal inheritance. These data give an estimated mutation rate (micro) of 0.55 mutations/site/Myrs (HPD 95% confidence interval of 0.29-0.88 mutations/site/Myrs) after accounting for the persistence of these heteroplasmies and the sensitivity of current detection methods. In comparison, the rate of evolution (k) of the same HVR I region, determined using DNA sequences from 162 known age sub-fossil bones spanning a 37,000-year period, was 0.86 substitutions/site/Myrs (HPD 95% confidence interval of 0.53 and 1.17). Importantly, the latter rate is not statistically different from our estimate of the mutation rate. These results are in contrast to the view that molecular rates are time dependent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.