ArticleArteriosclerosis, thrombosis, and vascular biology2008
Hypercholesterolemia enhances 15-lipoxygenase-mediated vasorelaxation and acetylcholine-induced hypotension.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Review
- Mammalian lipoxygenases and their biological relevance.Biochimica et biophysica acta · 2015Review
- The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis.Science signaling · 2013Article
- 12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction.The Journal of biological chemistry · 2013Article
- Hypercholesterolemia and microvascular dysfunction: interventional strategies.Journal of inflammation (London, England) · 2010Article
- Aspirin resistance with genetic dyslipidemia: contribution of vascular thromboxane generation.Physiological genomics · 2010Article
- Differential impact of familial hypercholesterolemia and combined hyperlipidemia on vascular wall and network remodeling in mice.Microcirculation (New York, N.Y. : 1994) · 2010Article
- Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries.The Journal of biological chemistry · 2009Article
- Role of arachidonic acid lipoxygenase metabolites in the regulation of vascular tone.American journal of physiology. Heart and circulatory physiology · 2009Review
- Endothelial nitric oxide and 15-lipoxygenase-1 metabolites independently mediate relaxation of the rabbit aorta.Vascular pharmacologyArticle
Corrections and comments
- Retraction · 2013-12-01Falsification/Fabrication of Data · Falsification/Fabrication of Image · Investigation by Company/Institution ·
- Commented on by
- Commented on by
- Retracted
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveArachidonic acid (AA) metabolites from 15-lipoxygenase-1 (15-LO-1), trihydroxyeicosatrienoic acid (THETA), and hydroxyepoxyeicosatrienoic acid (HEETA) relax arteries. We studied 15-LO-1 expression, THETA and HEETA synthesis, and their effect on arterial relaxations and blood pressure in hypercholesterolemic nonatherosclerotic rabbits. METHODS AND
resultsImmunoblots, RTPCR analysis, and (14)C-AA metabolism revealed that hypercholesterolemia increased 15-LO-1 expression in the endothelium and THETA and HEETA synthesis in the arteries. Isometric tension recording, in presence of nitric oxide synthase (NOS) and cyclooxygenase (COX) inhibitors, showed greater relaxations to acetylcholine (ACH) and AA (max 76.0+/-4.6% and 79.5+/-2.4%, respectively) in aortas from hypercholesterolemic rabbits compared with normal rabbits (max 39.1+/-2.8% and 39.9+/-2.2%, respectively). AA induced greater hyperpolarization in the smooth muscle cells of hypercholesterolemic aortas (-45.85+/-3.0 mV) compared with normal aortas (-31.45+/-1.9 mV). The ACH- and AA-relaxations were inhibited by 15-LO-1 inhibitors. ACH induced hypotensive responses were greater in hypercholesterolemic rabbits in absence (-54.9+/-3.3%) or presence (-48.5+/-3.2%) of NOS and COX-inhibitors compared with control rabbits (-31.6+/-3.3% and -24.3+/-1.6%, respectively). BW755C reduced these responses in hypercholesterolemic rabbits to -29.3+/-2.3%.
conclusionsHypercholesterolemia increases endothelial 15-LO-1 expression, THETA and HEETA synthesis and enhances vasorelaxation.
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Registered trials
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