ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.The Journal of biological chemistry · 2013Trial
- An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Exposure to Lead (Pb) Exacerbates Immunological Abnormalities in BTBR TInternational journal of molecular sciences · 2023Article
- Intrinsic STAT4 Expression Controls Effector CD4 T Cell Migration and Th17 Pathogenicity.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Effector T Helper Cell Subsets in Inflammatory Bowel Diseases.Frontiers in immunology · 2018Review
- Article
- STAT4 deficiency reduces the development of atherosclerosis in mice.Atherosclerosis · 2015Article
- Altered STAT4 Isoform Expression in Patients with Inflammatory Bowel Disease.Inflammatory bowel diseases · 2015Article
- STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.Journal of neuroinflammation · 2015Article
- Translational utility of experimental autoimmune encephalomyelitis: recent developments.Journal of inflammation research · 2015Review
- Th17 cells demonstrate stable cytokine production in a proallergic environment.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Serine protease inhibition attenuates rIL-12-induced GZMA activity and proinflammatory events by modulating the Th2 profile from estrogen-treated mice.Endocrinology · 2014Article
- STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity.Molecular and cellular biology · 2014Article
- Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Abnormal genetic and epigenetic changes in signal transducer and activator of transcription 4 in the pathogenesis of inflammatory bowel diseases.Digestive diseases and sciences · 2012Article
- Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells.British journal of cancer · 2011Article
- The multi-faceted influences of estrogen on lymphocytes: toward novel immuno-interventions strategies for autoimmunity management.Clinical reviews in allergy & immunology · 2011Review
- IL-7Rα confers susceptibility to experimental autoimmune encephalomyelitis.Genes and immunity · 2011Article
- Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis.Immunology · 2010Article
- Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.PloS one · 2010Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Experimental allergic encephalomyelitis (EAE) is a T cell-mediated autoimmune disease model of multiple sclerosis. Signal transducer and activator of transcription 4 (Stat4) is a transcription factor activated by IL-12 and IL-23, two cytokines known to play important roles in the pathogenesis of EAE by inducing T cells to secrete IFN-gamma and IL-17, respectively. We and others have previously shown that therapeutic intervention or targeted disruption of Stat4 was effective in ameliorating EAE. Recently, a splice variant of Stat4 termed Stat4beta has been characterized that lacks 44 amino acids at the C terminus of the full-length Stat4alpha. In this study we examined whether T cells expressing either isoform could affect the pathogenesis of EAE. We found that transgenic mice expressing Stat4beta on a Stat4-deficient background develop an exacerbated EAE compared with wild-type mice following immunization with myelin oligodendrocyte glycoprotein peptide 35-55, while Stat4alpha transgenic mice have greatly attenuated disease. The differential development of EAE in transgenic mice correlates with increased IFN-gamma and IL-17 in Stat4beta-expressing cells in situ, contrasting increased IL-10 production by Stat4alpha-expressing cells. This study demonstrates that Stat4 isoforms differentially regulate inflammatory cytokines in association with distinct effects on the onset and severity of EAE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.